| Project/Area Number |
25861510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
KOIDE Keiko 昭和大学, 医学部, 講師 (90384437)
SEKIZAWA Akihiko 昭和大学, 医学部, 教授 (10245839)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胎児発育 / 胎盤 / DNAメチル化 / 胎児発育不全 |
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| Outline of Final Research Achievements |
Villous DNA methylation profiles in dichorionic diamniotic twins were analyzed.
123 CpG sites were extracted as CpG site whose DNA methylation status altered in fetus with fetal growth restriction compared with the twin sibling grew up normally and was not significantly different in the twin siblings who both grew up normally. It was suggested that the alteration of villous DNA methylation at the CpG sites extracted in this study were associated with the pathogenesis of fetal growth restriction.
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