Cyclic AMP signaling network in the decidualization of endometrial stromal cells
| Project/Area Number |
25861511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脱落膜化 / EPAC / cAMP / Epac / 子宮内膜腺の成熟 / Calreticulin / PKA |
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| Outline of Final Research Achievements |
Decidualization (differentiation) of human endometrial stroma and gland development, which are indispensable for the establishment and maintenance of pregnancy are regulated by cyclic AMP-mediated signaling pathway. We demonstrated the cooperative function of canonical protein kinase A and Exchange protein directly activated by cAMP (Epac)-mediated cAMP signaling in decidualization. We also clarified the crucial role of Epac signaling associated factors in decidualization and maturation of endometrial glandular cells.
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Report
(4 results)
Research Products
(28 results)
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[Presentation] Involvement of cAMP signaling mediators, Epac1, Epac2, and Rap1 in decidualization of rat uterus2014
Author(s)
M. Yoshie, K. Kusama, K. Tamura, T. Daikoku, T. Takarada, and E. Tachikawa
Organizer
The 16th International Congress of Endocrinology & The Endocrine Society's 96th Annual Meeting & Expo（Chicago, USA）
Place of Presentation
Chicago, USA
Year and Date
2014-06-21 – 2014-06-24
Related Report
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