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Cell treatment model for implantation failure using mesenchymal stem cells

Research Project

Project/Area Number 25861518
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionNational Center for Child Health and Development

Principal Investigator

SUGAWARA Kana  国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 研究員 (10453739)

Research Collaborator UMEZAWA Akihiro  国立成育医療研究センター, 細胞医療研究部, 部長
HAMATANI Toshio  慶應義塾大学, 医学部・産婦人科学教室, 講師
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords着床不全 / 間葉系幹細胞 / 脱落膜化
Outline of Final Research Achievements

We induced differentiation of human amnion-derived mesenchymal stem cells (AMCs) and menstrual blood-derived mesenchymal stem cells (MMCs) into endometrial stroma-like cells, which could be useful for cell therapy to support embryo implantation. Interestingly, the expression patterns of surface markers were similar among AMCs, MMCs, and endometrial stromal cells. In addition, whereas treatment with estrogen and progesterone was not very effective for decidualizing AMCs and MMCs, treatment with 8-Br-cAMP prompted remarkable morphological changes in these cells as well as increased expression of decidualization markers and attenuated expression of surface markers unique to mesenchymal stem cells. These results demonstrated that bone marrow-derived stem cells, which are considered a potential source of endometrial progenitor cells, as well as AMCs and MMCs show in vitro decidualization potential, which is characteristic of endometrial stromal cells.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Derivation of human decidua-like cells from amnion and menstrual blood2014

    • Author(s)
      Sugawara K, Hamatani T, Yamada M, Ogawa S, Kamijo S, Kuji N, Akutsu H, Miyado K, Yoshimura Y, Umezawa A
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 4599-4599

    • DOI

      10.1038/srep04599

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒト間葉系幹細胞から子宮内膜間質様細胞への分化誘導2014

    • Author(s)
      菅原かな、浜谷敏生、小川誠司、上條慎太郎、竹本崇史、戸田里実、若松修平、久慈直昭、阿久津英憲、梅澤明弘、吉村泰典、青木大輔
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト間葉系幹細胞から子宮内膜間質様細胞への分化誘導2013

    • Author(s)
      菅原かな、浜谷敏生、小川誠司、山田満稔、 奥村典子、福永朝子、井上治、上條慎太郎、 久慈直昭、梅澤明弘、青木大輔、吉村泰典
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト間葉系幹細胞から子宮内膜間質細胞への分化誘導2013

    • Author(s)
      菅原かな、浜谷敏生、小川誠司、山田満稔、山田朝子、上條慎太郎、竹本崇史、戸田里実、若松修平、久慈直昭、阿久津英憲、梅澤明弘、吉村泰典
    • Organizer
      第58回日本生殖医学会学術講演会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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