| Project/Area Number |
25861523
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌幹細胞 / CD44 / 放射線 / 予後因子 / 放射線によるCD44の変化と悪性度の関連性 |
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| Outline of Final Research Achievements |
Radiation therapy has been a major contribution to the improvement of life prognosis in head and neck cancer. However, There is also something of radiation resistance in, there is the existence of cancer stem cells has been suggested. It is widely known CD44 as a marker of head and neck cancer stem cells. By radiation, it was examined whether there occurs a change in CD44. The five cell lines was subjected to irradiation 60Gy, was confirmed by flow cytometer change of isoform before and after, CD44std decrease, CD44v6 is unchanged or increased, CD44v3 was found to have increased. It is necessary to consider in detail whether the change of this isoform contributes to malignancy in the future.
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