facial nerve regeneration by Muse cell

• Project/Area Number: 25861524
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Yamagata University
• Principal Investigator: Furukawa Takatoshi 山形大学, 医学部, 助教 (80466630)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 顔面神経麻痺 / 再生 / Muse細胞 / ラット / 顔面神経損傷 / 神経回復 / Muse 細胞 / 多能性幹細胞

Outline of Final Research Achievements

We use facial nerve cut models of rats. We transplanted 75% L-lactic acid and 25% E-caprolactone tube to cut sites and administered human Muse cells to these models using drugs to suppress the immune system. We can get results of slow recover of nerve regeneration. From now we are going to measure numbers of axon and thickness of myelin sheath in regenerated nerve.

Research Products

• [Journal Article] 当科における外傷性顔面神経麻痺の検討 (2015)
  • Author(s): 古川孝俊, 稲村博雄, 阿部靖弘, 後藤崇成, 青柳 優, 欠畑誠治
  • Journal Title: Facial N Res Volume: 35 Pages: 59-61
  • Peer Reviewed
• [Journal Article] 古川孝俊, 稲村博雄：Bell麻痺、Hunt症候群に対する抗ウイルス薬投与の実際 (2015)
  • Author(s): 古川孝俊, 稲村博雄
  • Journal Title: JOHNS Volume: 31 Pages: 717-720
• [Journal Article] Epstein-Barr virus in the enlarged salivary tissues of patients with IgG4-related disease (2015)
  • Author(s): Furukawa T, Shimotai Y, OhtaN, Ishida A, Kurakami K, Suzuki H, et al
  • Journal Title: laryngoscope Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 当院におけるBell麻痺・Hunt症候群に対するENoG検査の導出部位別の検討 (2015)
  • Author(s): 佐藤葉子 古川孝俊 東海林悠 多田美智子 渡邊真由美 長瀬輝顕
  • Journal Title: 山形県立病院誌 Volume: 印刷中
  • NAID: 40020507641
  • Peer Reviewed
• [Journal Article] Bell麻痺・Hunt症候群の予後の再検討 (2014)
  • Author(s): 古川孝俊，稲村博雄，阿部靖弘，千田邦明，青柳 優，欠畑誠治
  • Journal Title: Facial N Res Jpn Volume: 34 Pages: 120-122
  • Peer Reviewed
• [Journal Article] 乳突削開後に改善した２歳両側同時性顔面神経麻痺の１例 (2014)
  • Author(s): 古川孝俊，渡辺知緒，伊藤 吏，窪田俊憲，稲村博雄，欠畑誠治
  • Journal Title: Otol Jpn Volume: 24 Pages: 221-226
  • Peer Reviewed
• [Journal Article] Feasibility and Advantages of Transcanal Endoscopic Myringoplasty (2014)
  • Author(s): Furukawa T, Watanabe T, Ito T, Kubota T, Kakehata S
  • Journal Title: otology & neurotology Volume: 35巻 Pages: 140-145
  • Peer Reviewed
• [Journal Article] 簡便な麻痺重症度の判定法―兎眼の有無での判定の試み― (2013)
  • Author(s): 古川孝俊，稲村博雄，千田邦明，青柳 優，欠畑誠治
  • Journal Title: Facial Nerve Research Japan Volume: 33巻 Pages: 100-102
  • Peer Reviewed
• [Presentation] 当科顔面神経疾患患者の臨床統計 (2015)
  • Author(s): 古川孝俊, 渡邊知緒, 伊藤 吏,阿部靖弘, 後藤崇成,欠畑誠治
  • Organizer: 日耳鼻山形県地方部会
  • Place of Presentation: 山形大学医学部、山形市
  • Year and Date: 2015-12-12
• [Presentation] 当科におけるBell麻痺症例の統計学的検討 (2015)
  • Author(s): 古川孝俊, 稲村博雄, 阿部靖弘, 渡辺知緒, 伊藤 吏, 窪田俊憲, 松井祐興, 青柳 優,欠畑誠治
  • Organizer: 第25回日本耳科学会
  • Place of Presentation: プリックホール長崎、長崎市
  • Year and Date: 2015-10-08
• [Presentation] 当科における外傷性顔面神経麻痺の検討 (2015)
  • Author(s): 古川孝俊，稲村博雄，阿部靖弘，後藤崇成，青柳 優，欠畑誠治
  • Organizer: 第38回日本顔面神経学会
  • Place of Presentation: 東京大学、東京都
  • Year and Date: 2015-06-11
• [Presentation] Retrospective Review of Treatment for Severe Cases of Bell’s Palsy and Ramsay Hunt Syndrome (2015)
  • Author(s): Takatoshi Furukawa, Yasuhiro Abe, Tomoo Watanabe, Tsukasa Ito, Toshinori Kubota, Seiji Kakehata
  • Organizer: 50th annual meeting American Neurotology society
  • Place of Presentation: America Boston
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Bell麻痺・Hunt症候群の予後の再検討 (2014)
  • Author(s): 古川孝俊，稲村博雄，阿部靖弘，千田邦明，青柳 優，欠畑誠治
  • Organizer: 第37回日本顔面神経学会
  • Place of Presentation: 東京、東京平成大学
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] Useful cases of multiple cholesteatomas by image fusion between non-EPI DW-MRI and MRC images (2014)
  • Author(s): Furukawa T, Watanabe T, Ito T, Abe Y, Kubota T, Futai K, Kakehata S
  • Organizer: 147th annual meeting American otological society
  • Place of Presentation: Caesars Palace、アメリカ、ラスベガス
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] Feasibility and Advantages of Transcanal Endoscopic Myringoplasty (2013)
  • Author(s): Furukawa T
  • Organizer: 146th annual meeting American otological society
  • Place of Presentation: JW Marriott Grande Lakes Resort (America Orlando)
• [Presentation] 簡便な麻痺重症度の判定法―兎眼の有無での判定の試み― (2013)
  • Author(s): 古川孝俊
  • Organizer: 第36回日本顔面神経研究会
  • Place of Presentation: ロワジールホテル那覇（沖縄）
• [Funded Workshop] 50th annual meeting American Neurotology society (2015)
  • Place of Presentation: Boston
  • Year and Date: 2015-04-26