Development of therapeutic strategies targeting cancer-associated fibroblasts
| Project/Area Number |
25861525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gunma University |
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Principal Investigator |
Toyoda Minoru 群馬大学, 医学(系)研究科(研究院), 助教 (70344942)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌 / 免疫学 |
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| Outline of Final Research Achievements |
We investigated whether cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) in head and neck squamous cell carcinoma (SCCHN) contributed to promoting immunosuppression and evasion from immune surveillance.
CAFs suppressed T cell proliferation through B7H1/B7DC, TGF-beta, and VEGF. Moreover, peripheral blood mononuclear cells co-cultured with the supernatants of CAFs preferentially induced T cell apoptosis and regulatory T cells. CAFs could induce the immunosuppressive phenotype of tumor-associated macrophages, and the high intensity of CAFs was the significant independent prognostic factor of SCCHN. Thus, CAFs would collaborate with tumor cells in the TME to establish an immunosuppressive network.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma.2015
Author(s)
Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Pathol Oncol Res.
Volume: 21
Pages: 1175-1181
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CD98 is a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.2015
Author(s)
Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Head Neck
Volume: in press
Pages: 1569-1574
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma.2014
Author(s)
Toyoda M, Kaira K, Ohshima Y, Ishioka NS, Shino M, Sakakura K, Takayasu Y, Takahashi K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Br J Cancer
Volume: 110
Pages: 2506-13
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer.2014
Author(s)
Toyoda M, Kaira K, Ohshima Y, Ishioka NS, Shino M, Sakakura K, Takayasu Y, Takahashi K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Br J Cancer
Volume: in press
Related Report
Peer Reviewed
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