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Development of therapeutic strategies targeting cancer-associated fibroblasts

Research Project

Project/Area Number 25861525
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionGunma University

Principal Investigator

Toyoda Minoru  群馬大学, 医学(系)研究科(研究院), 助教 (70344942)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌 / 免疫学
Outline of Final Research Achievements

We investigated whether cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) in head and neck squamous cell carcinoma (SCCHN) contributed to promoting immunosuppression and evasion from immune surveillance.
CAFs suppressed T cell proliferation through B7H1/B7DC, TGF-beta, and VEGF. Moreover, peripheral blood mononuclear cells co-cultured with the supernatants of CAFs preferentially induced T cell apoptosis and regulatory T cells. CAFs could induce the immunosuppressive phenotype of tumor-associated macrophages, and the high intensity of CAFs was the significant independent prognostic factor of SCCHN. Thus, CAFs would collaborate with tumor cells in the TME to establish an immunosuppressive network.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (13 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.2016

    • Author(s)
      Kaira K, Toyoda M, Shimizu A, Shino M, Sakakura K, Takayasu Y, Takahashi K, Asao T, Chikamatsu K.
    • Journal Title

      Acta Otolaryngol

      Volume: 136 Issue: 1 Pages: 1-7

    • DOI

      10.3109/00016489.2015.1083120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma.2015

    • Author(s)
      Takahashi H, Sakakura K, Kawabata-Iwakawa R, Rokudai S, Toyoda M, Nishiyama M, Chikamatsu K.
    • Journal Title

      Cancer Immunol Immunother

      Volume: 64 Issue: 11 Pages: 1407-1417

    • DOI

      10.1007/s00262-015-1742-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma.2015

    • Author(s)
      Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
    • Journal Title

      Pathol Oncol Res

      Volume: 21 Issue: 4 Pages: 1175-1181

    • DOI

      10.1007/s12253-015-9954-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 遺伝子検査による後発リンパ節転移の予測.2015

    • Author(s)
      高橋克昌, 中島恭子, 紫野正人, 豊田実, 高安幸弘, 近松一朗.
    • Journal Title

      日耳鼻

      Volume: 118 Pages: 135-139

    • NAID

      130004914055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-FDG uptake on PET correlates with biological potential in early oral squamous cell carcinoma.2015

    • Author(s)
      Yokobori Y, Toyoda M, Sakakura K, Kaira K, Tsushima Y, Chikamatsu K.
    • Journal Title

      Acta Otolaryngol

      Volume: in press Issue: 5 Pages: 494-499

    • DOI

      10.3109/00016489.2014.969385

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.2015

    • Author(s)
      Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 1 Pages: 1-8

    • DOI

      10.1111/cas.12559

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.2014

    • Author(s)
      Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
    • Journal Title

      Head Neck.

      Volume: in press Issue: 11 Pages: 1-6

    • DOI

      10.1002/hed.23797

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer.2014

    • Author(s)
      Toyoda M, Kaira K, Ohshima Y, Ishioka NS, Shino M, Sakakura K, Takayasu Y, Takahashi K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
    • Journal Title

      Br J Cancer.

      Volume: 110 Issue: 10 Pages: 2506-13

    • DOI

      10.1038/bjc.2014.178

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer.2014

    • Author(s)
      Toyoda M, Kaira K, Ohshima Y, Ishioka NS, Shino M, Sakakura K, Takayasu Y, Takahashi K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
    • Journal Title

      Br J Cancer

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma.2013

    • Author(s)
      Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Kanai Y, Oyama T, Chikamatsu K.
    • Journal Title

      Pathol. Oncol. Res.

      Volume: 19 Issue: 4 Pages: 649-656

    • DOI

      10.1007/s12253-013-9624-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck.2013

    • Author(s)
      Chikamatsu K, Ishii H, Murata T, Sakakura K, Shino M, Toyoda M, Takahashi K, Masuyama K.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 11 Pages: 1468-1475

    • DOI

      10.1111/cas.12271

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 赤外線サーモグラフィによる遊離空腸再建後・モニター空腸の状況判断2015

    • Author(s)
      紫野正人,豊田実、村田考啓、宮崎達也、宗田真、酒井真、桑野博行、近松一朗
    • Organizer
      第67回日本気管食道科学会
    • Place of Presentation
      福島
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Possible relation between tumor-associated macrophage (TAM) subsets and CD47 expression on squamous cell carcinoma of the head and neck (SCCHN) in tumor microenvironment2015

    • Author(s)
      Sakakura K, Takahashi H, Kaira K, Toyoda M, Chikamatsu K.
    • Organizer
      International Conference of Cancer Immunotherapy and Macrophages
    • Place of Presentation
      東京
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 気道熱傷後の気管挿管により形成された声門下肉芽の1例2015

    • Author(s)
      御任一光、井田翔太、矢島美香、中島恭子、岡宮智史、豊田実、近松一朗
    • Organizer
      第77回耳鼻咽喉科臨床学会
    • Place of Presentation
      浜松
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 上咽頭腫瘍から内頚動脈狭窄による脳梗塞を発症した1例2015

    • Author(s)
      井田翔太、御任一光、矢島美香、中島恭子、岡宮智史、豊田実、近松一朗
    • Organizer
      第77回耳鼻咽喉科臨床学会
    • Place of Presentation
      浜松
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 群馬大学における頭頸部悪性腫瘍に対する重粒子線治療の短期成績2015

    • Author(s)
      高安幸弘、紫野正人、豊田実、新国摂、高橋克昌、近松一朗、斎藤淳一、白井克幸、 大野達也、中野隆史
    • Organizer
      第116回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Immunological significance of autophagy components accumulated in oral squamous cell carcinoma2014

    • Author(s)
      Koichi Sakakura, Minoru Toyoda, Tetsunari Oyama, Kazuaki Chikamatsu
    • Organizer
      IFHNOS 5th World Congress And AHNS Annual Meeting
    • Place of Presentation
      New York
    • Year and Date
      2014-07-26 – 2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Biological significance of 18F-FDG PET in early stage oral squamous cell carcinoma2014

    • Author(s)
      Yuki Yokobori, Minoru Toyoda, Koichi Sakakura, Kyoichi Kaira, Kazuaki Chikamatsu
    • Organizer
      IFHNOS 5th World Congress And AHNS Annual Meeting
    • Place of Presentation
      New York
    • Year and Date
      2014-07-26 – 2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 気管切開孔と胃瘻部に転移をきたした舌癌の1例2014

    • Author(s)
      豊田実、矢島美香、宮﨑眞祈、近松一朗
    • Organizer
      第76回耳鼻咽喉科臨床学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2014-06-26 – 2014-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 口腔扁平上皮癌におけるautophagy関連分子の発現と腫瘍浸潤免疫細胞との関係2014

    • Author(s)
      坂倉浩一、高橋秀行、解良恭一、豊田実、小山徹也、近松一朗
    • Organizer
      第115回日本耳鼻咽喉科学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Biological markers as predictors of clinical outcome in adenoid cystic carcinoma of the head and neck.2013

    • Author(s)
      Toyoda M, Sakakura K, Yokobori Y, Chikamatsu K.
    • Organizer
      Combined Otolaryngology Spring Meeting
    • Place of Presentation
      Orlando, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭頸部腺様嚢胞癌の新しい予後のマーカーの検討2013

    • Author(s)
      豊田実、坂倉浩一、解良恭一、横堀有紀、近松一朗
    • Organizer
      第114回日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭頸部腺様嚢胞癌の新しい予後マーカーの検討2013

    • Author(s)
      豊田実、坂倉浩一、解良恭一、横堀有紀、近松一朗
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 耳下腺に生じた衝突腫瘍の1例2013

    • Author(s)
      豊田実、横堀有紀、近松一朗
    • Organizer
      第75回耳鼻咽喉科臨床学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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