| Project/Area Number |
25861528
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイクロRNA / 頭頸部癌 / 唾液腺導管癌 / microrna / マイクロアレイ |
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| Outline of Final Research Achievements |
Salivary duct carcinoma (SDC) is an aggressive disease with poor prognosis. Despite of multimodal therapies (surgical resection with neck dissection, radiation and chemotherapy), SDC frequently occurs local recurrence, and metastasizes to distant organs, such as lung, bone and liver. Most patients die within four years of diagnosis. There is no established treatment protocol for this disease even now. In this study, we constructed gene expression signatures (messenger RNA and microRNA) of SDC and tried to identify the molecular mechanisms that characterize of the disease. Our expression data revealed that ECM-related genes were significantly upregulated in SDC specimens. Moreover, microRNA-29b was significantly reduced in SDC and this microRNA act as a tumor suppressor in cancer cells. Interestingly, microRNA-29b regulates ECM-related genes by in silico analysis. Identification of novel mRNA/microRNA networks could provide new insights into underlying molecular mechanisms of SDC.
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