| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The current study aimed to develop a new therapy for allergic rhinitis using NKT cell-mediated immunity system with enhanced therapeutic efficacy and a shortened duration of treatment without serious adverse events. TCRs of iNKT cells recognize monomorphic major histocompatibility complex (MHC) class I-like CD1d molecules on antigen-presenting cells (APCs), and glycolipid antigens such as α-galactosylceramide (α-GalCer) presented on CD1d preferentially activate iNKT Cells. In this study, we administered ovalbumin (OVA)- and α-GalCer-pulsed bone marrow-derived dendritic cells (BMDCs) into the oral submucosa of OVA-sensitized mice and examined the role of activated iNKT cells in an Allergi rhinitis mouse model. Administration of OVA/α-GalCer-pulsed BMDCs suppressed antigen-specific responses.
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