Anti-aging of voice: investigation of mechanism, treatment, and prevention of vocal aging

• Project/Area Number: 25861530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAUCHI Akihito 東京大学, 医学部附属病院, 登録研究医 (90612507)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アンチエイジング / 音声 / 老化 / カロリー制限 / 声帯 / 老人性喉頭 / 声帯萎縮

Outline of Final Research Achievements

The present study aimed at the investigation of clinical profile of presbyphonia, a recently-increasing laryngeal pathology, and the establishment of therapeutic or preventive measures toward presbyphonia. First, the clinical characteristics of patients with presbyphonia in comparison with vocally healthy subjects were clarified through clinical research. Second, the impact of calorie restriction, a representative measure of anti-aging, on vocal folds was investigated through basic research using male rats, the preliminary results of which showed that calorie restriction might have beneficial influence on vocal folds.

Research Products

• [Journal Article] Vocal Fold Vibration in Vocal Fold Atrophy: Quantitative Analysis With High-Speed Digital Imaging. (2015)
  • Author(s): Yamauchi A, Yokonishi H, Imagawa H, Sakakibara KI, Nito T, Tayama N, Yamasoba T.
  • Journal Title: J Voice Volume: 29 Issue: 6 Pages: 755-762
  • DOI: 10.1016/j.jvoice.2014.12.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Quantitative Analysis of Digital Videokymography: A Preliminary Study on Age- and Gender-Related Difference of Vocal Fold Vibration in Normal Speakers (2014)
  • Author(s): A. Yamauchi, H. Yokonishi, H. Imagawa, K.-I. Sakakibara, T. Nito, N. Tayama, and T. Yamasoba
  • Journal Title: J. Voice Volume: 29(1) Issue: 1 Pages: 109-119
  • DOI: 10.1016/j.jvoice.2014.05.006
  • Peer Reviewed
• [Journal Article] Characteristics of Vocal Fold Vibrations in Vocally Healthy Subjects: Analysis with Multi-line Kymography. (2014)
  • Author(s): Yamauchi, A., Imagawa, H., Sakakibara, K-I., Yokonishi, H.,Ueha R, Nito, T., Yamasoba, T., Tayama, N.
  • Journal Title: J Speech Lang Hear Res Volume: 57 Issue: 2
  • DOI: 10.1044/2014_jslhr-s-12-0269
  • Peer Reviewed
• [Journal Article] Vocal Fold Atrophy in a Japanese Tertiary Medical Institute: Status Quo of the Most Aged Country. (2014)
  • Author(s): Yamauchi A, Imagawa H, Sakakaibara K, Yokonishi H, Ueha R, Nito T, Tayama N, Yamasoba T.
  • Journal Title: J voice Volume: 28 Issue: 2 Pages: 231-236
  • DOI: 10.1016/j.jvoice.2013.07.003
  • Peer Reviewed
• [Journal Article] Age- and gender-related difference of vocal fold vibration and glottal configuration in normal speakers: analysis with glottal area waveform. (2014)
  • Author(s): Yamauchi, A., Imagawa, H., Sakakibara, K-I., Yokonishi, H., Nito, T., Yamasoba, T., Tayama, N.
  • Journal Title: J voice Volume: 28
  • Peer Reviewed
• [Presentation] Quantitative analysis of vocal fold vibration in various voice disorders using high-speed digital imaging. (2015)
  • Author(s): Akihito Yamauchi
  • Organizer: 13th Asia-Oceania ORL-HNS Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-03-19 – 2015-03-22
  • Invited
• [Presentation] 高速度デジタル撮像を用いた声帯振動の標準的評価法の提案 (2014)
  • Author(s): 山内彰人, 今川博, 横西久幸, 上羽瑠美, 二藤隆春, 榊原健一, 田山二朗, 山岨達也
  • Organizer: 第115回日本耳鼻咽喉科科学会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] Qualitative and quantitative assessment of high-speed digital imaging with combined analysis method (2014)
  • Author(s): Akihito Yamauchi, Hiroshi Imagawa, Hisayuki Yokonishi, Rumi Ueha, Takaharu Nito, Ken-Ichi Sakakibara, Niro Tayama, Tatsuya Yamasoba.
  • Organizer: The 9th International Conference on Voice Physiology and Biomechanics
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2014-04-21 – 2014-04-23
• [Presentation] 声帯萎縮に対する声帯内注入術の治療効果：年齢・性別に関する比較 (2013)
  • Author(s): 山内彰人, 二藤隆春, 山岨達也
  • Organizer: 第13回抗加齢医学会
  • Place of Presentation: 横浜
• [Presentation] Vocal fold atrophy patients in a Japanese tertiary medical institute: demographics and treatment (2013)
  • Author(s): Akihito Yamauchi, Hiroshi Imagawa, Hisayuki Yokonishi, Rumi Ueha, Ken-Ichi Sakakibara, Niro Tayama, Tatsuya Yamasoba
  • Organizer: 10th Pan-European Voice Conference
  • Place of Presentation: チェコ、プラハ
• [Presentation] Analysis of vocal fold vibrations using high-speed digital imaging in patients with vocal fold paralysis (2013)
  • Author(s): Akihito Yamauchi, Hiroshi Imagawa, Hisayuki Yokonishi, Rumi Ueha, Ken-Ichi Sakakibara, Niro Tayama, Tatsuya Yamasoba
  • Organizer: 10th Pan-European Voice Conference
  • Place of Presentation: チェコ、プラハ
• [Presentation] 高速度デジタル撮像を用いた様々な喉頭疾患における声帯振動の定性的・定量的解析 (2013)
  • Author(s): 山内彰人, 今川博, 横西久幸, 上羽瑠美, 二藤隆春, 榊原健一, 田山二朗, 山岨達也
  • Organizer: 第58回日本音声言語医学会
  • Place of Presentation: 高知