Establishment of inner ear protection by nutrient regulation.

• Project/Area Number: 25861532
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: FUJIMOTO Chisato 東京大学, 医学部附属病院, 助教 (60581882)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 内耳 / 内耳障害 / オートファジー / ミトコンドリア / 神経科学 / 耳鼻咽喉科学

Outline of Final Research Achievements

In the present study, we focused on mTORC1 complex signaling to estabilsh a new method for inner ear protection. Inhibition of mTORC1 signaling induces autophagy, which contributes to the cellular quality control such as clearance of damaged mitochondria. We established the evaluation system of the autophagic activity in the cochlear hair cells by using cochlear explant culture of GFP-LC3 transgenic mice, which can monitor autophagy.

Research Products

• [Journal Article] Involvement of vestibular organs in idiopathic sudden hearing loss with vertigo: An analysis using oVEMP and cVEMP testing. (2015)
  • Author(s): Fujimoto C, Egami N, Kinoshita M, Sugasawa K, Yamasoba T, Iwasaki S.
  • Journal Title: Clin Neurophysiol. Volume: 126 Issue: 5 Pages: 1033-8
  • DOI: 10.1016/j.clinph.2014.07.028
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effect of center-of-pressure power spectrum in foam posturography. (2015)
  • Author(s): Fujimoto C, Egami N, Demura S, Yamasoba T, Iwasaki S.
  • Journal Title: Neurosci Lett. Volume: 585 Pages: 92-7
  • DOI: 10.1016/j.neulet.2014.11.033
  • Peer Reviewed
• [Journal Article] Clinical Characteristics of Patients With Abnormal Ocular/Cervical Vestibular Evoked Myogenic Potentials in the Presence of Normal Caloric Responses. (2015)
  • Author(s): Iwasaki S, Fujimoto C, Kinoshita M, Kamogashira T, Egami N, Yamasoba T.
  • Journal Title: Ann Otol Rhinol Laryngol. Volume: 124 Pages: 458-65
  • Peer Reviewed
• [Journal Article] Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss. (2015)
  • Author(s): Kamogashira T, Fujimoto C, Yamasoba T
  • Journal Title: Biomed Research International Volume: 2015 Pages: 617207-617207
  • DOI: 10.1155/2015/617207
  • Peer Reviewed / Open Access
• [Journal Article] Noisy vestibular stimulation improves body balance in bilateral vestibulopathy. (2014)
  • Author(s): Iwasaki S, Yamamoto Y, Togo F, Kinoshita M, Yoshifuji Y, Fujimoto C, Yamasoba T.
  • Journal Title: Neurology Volume: 82 Issue: 11 Pages: 969-975
  • DOI: 10.1212/wnl.0000000000000215
  • Peer Reviewed
• [Journal Article] Developmental changes in the protective effect of exogenous brain-derived neurotrophic factor and neurotrophin-3 against ototoxic drugs in cultured rat vestibular ganglion. (2014)
  • Author(s): Inoue A, Iwasaki S, Fujimoto C, Nakajima T, Yamasoba T
  • Journal Title: Cell Tissue Res Volume: 356 Issue: 2 Pages: 299-308
  • DOI: 10.1007/s00441-014-1813-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Oxidative stresses and mitochondrial dysfunction in age-related hearing loss. (2014)
  • Author(s): Fujimoto C, Yamasoba T.
  • Journal Title: Oxid Med Cell Longev Volume: 2014 Pages: 582849-582849
  • DOI: 10.1155/2014/582849
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Power spectral analysis of postural sway during foam posturography in patients with peripheral (2014)
  • Author(s): Fujimoto C, Kamogashira T, Kinoshita M, Egami N, Sugasawa K, Demura S, Yamasoba T, Iwasaki S.
  • Journal Title: Otol Neurotol. Volume: 35 Issue: 10 Pages: e317-e323
  • DOI: 10.1097/mao.0000000000000554
  • Peer Reviewed
• [Journal Article] Fujimoto C, Yamasoba T, Iwasaki S. Idiopathic latent vestibulopathy: a clinical entity as a cause of chronic postural instability. (2014)
  • Author(s): Fujimoto C, Yamasoba T, Iwasaki S.
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 272 Issue: 1 Pages: 43-49
  • DOI: 10.1007/s00405-013-2834-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Postural stability in vestibular neuritis: Age, disease duration, and residual vestibular function. (2014)
  • Author(s): Fujimoto C, Egami N, Kinoshita M, Sugasawa K, Yamasoba T, Iwasaki S.
  • Journal Title: The Laryngoscope Volume: 124 Issue: 4 Pages: 974-979
  • DOI: 10.1002/lary.24342
  • Peer Reviewed
• [Journal Article] Effect of vestibular dysfunction on the development of gross motor function in children with profound hearing loss. (2013)
  • Author(s): Inoue A, Iwasaki S, Ushio M, Chihara Y, Fujimoto C, Egami N, Yamasoba T.
  • Journal Title: Audiology & Neurotology Volume: 18 Issue: 3 Pages: 143-151
  • DOI: 10.1159/000346344
  • Peer Reviewed
• [Journal Article] Diagnostic usefulness of multifrequency tympanometry for Ménière's disease. (2013)
  • Author(s): Sugasawa K, Iwasaki S, Fujimoto C, Kinoshita M, Inoue A, Egami N, Ushio M, Chihara Y, Yamasoba T.
  • Journal Title: Audiology & Neurotology Volume: 18 Issue: 3 Pages: 152-160
  • DOI: 10.1159/000346343
  • Peer Reviewed
• [Journal Article] Ocular vestibular evoked myogenic potential elicited from binaural air-conducted stimulations: clinical feasibility in patients with peripheral vestibular dysfunction (2013)
  • Author(s): Iwasaki S, Egami N, Inoue A, Kinoshita M, Fujimoto C, Murofushi T, Yamasoba T.
  • Journal Title: Acta Otolaryngol Volume: 133 Issue: 7 Pages: 1342-1348
  • DOI: 10.3109/00016489.2013.767476
  • Peer Reviewed
• [Journal Article] Ocular vestibular evoked myogenic potentials in response to air-conducted sound and bone-conducted vibration in vestibular schwannoma. (2013)
  • Author(s): Kinoshita M, Iwasaki S, Fujimoto C, Inoue A, Egami N, Chihara Y, Ushio M, Yamasoba T.
  • Journal Title: Otology & Neurotology Volume: 34 Issue: 7 Pages: 1342-1348
  • DOI: 10.1097/mao.0b013e31828d6539
  • Peer Reviewed
• [Journal Article] The effect of a first-generation H1-antihistamine on postural control: a preliminary study in healthy volunteers. (2013)
  • Author(s): Chihara Y, Sato A, Ohtani M, Fujimoto C, Hayashi T, Nishijima H, Yagi M, Iwasaki S.
  • Journal Title: Experimental Brain Research Volume: 231 Issue: 3 Pages: 257-266
  • DOI: 10.1007/s00221-013-3675-1
  • Peer Reviewed
• [Journal Article] Factors affecting postural instability in Meniere's disease. (2013)
  • Author(s): Fujimoto C, Egami N, Kinoshita M, Sugasawa K, Yamasoba T, Iwasaki S.
  • Journal Title: Otolaryngology–Head and Neck Surgery Volume: 149 Issue: 5 Pages: 759-765
  • DOI: 10.1177/0194599813501625
  • Peer Reviewed
• [Journal Article] 一側性メニエール病症例が両側性に移行する要因についての検討 (2013)
  • Author(s): 牛尾 宗貴, 岩崎 真一, 江上 直也, 菅澤 恵子, 井上 亜希, 木下 淳, 千原 康裕, 藤本 千里, 室伏 利久, 山岨 達也
  • Journal Title: Equilibrium Research Volume: 72 Pages: 37-46
  • NAID: 10031155690
  • Peer Reviewed
• [Journal Article] 外来診療のワンポイントアドバイス めまい (2013)
  • Author(s): 藤本千里, 山岨達也
  • Journal Title: 診断と治療 Volume: 101 Pages: 1235-1239
  • NAID: 40019784118
• [Journal Article] 【検査結果をどう読むか?】 平衡覚領域の検査 重心動揺検査 (2013)
  • Author(s): 藤本千里
  • Journal Title: JOHNS Volume: 29 Pages: 1559-1562
• [Journal Article] 【めまいベーシック-日常診療における疑問に答える-】 重心動揺検査で何がわかるのか？ (2013)
  • Author(s): 藤本千里
  • Journal Title: JOHNS Volume: 29 Pages: 1843-1846
• [Journal Article] 特発性両側性末梢前庭機能低下症(idiopathic bilateral vestibulopathy:IBV) (2013)
  • Author(s): 藤本千里
  • Journal Title: Equilibrium Research Volume: 72 Pages: 501-503
  • Peer Reviewed
• [Presentation] THE EFFECT OF AGINGON THE CENTER-OF-PRESSURE POWER SPECTRUMIN FOAM POSTUROGRAPHY (2015)
  • Author(s): Chisato Fujimoto, Shinichi Iwasaki, Naoya Egami and Tatsuya Yamasoba
  • Organizer: 13th Asia-Oceania ORL-HNS Congress
  • Place of Presentation: 台北市
  • Year and Date: 2015-03-19 – 2015-03-22
• [Presentation] 内耳有毛細胞におけるオートファジーの役割 (2014)
  • Author(s): 藤本千里
  • Organizer: 第8回オートファジー研究会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-11-11 – 2014-11-12
• [Presentation] 特発性両側性末梢前庭機能低下症の臨床経過と障害部位に関する検討 (2014)
  • Author(s): 藤本千里、木下淳、鴨頭輝、江上直也、牛尾宗貴、菅澤恵子、山岨達也、岩崎真一
  • Organizer: 第73回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-05 – 2014-11-07
• [Presentation] 酸素消費速度を指標としたマウスコルチ器のミトコンドリア機能評価 (2014)
  • Author(s): 藤本千里、鴨頭輝、木下淳、岩崎真一、山岨達也
  • Organizer: 第24回日本耳科学会総会・学術講演会
  • Place of Presentation: 新潟市
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 末梢前庭障害患者におけるラバー負荷重心動揺検査のパワースペクトル解析 (2014)
  • Author(s): 藤本千里、岩崎真一、鴨頭輝、木下淳、江上直也、菅澤恵子、山岨達也
  • Organizer: 第115回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] 末梢前庭障害患者の体平衡評価 (2014)
  • Author(s): 藤本千里
  • Organizer: 第13回神奈川Neuro-Otology研究会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 前庭神経炎患者のラバー負荷重心動揺検査所見に影響を及ぼす因子の検討 (2013)
  • Author(s): 藤本千里，岩崎真一，木下淳，江上直也，菅澤恵子，山岨達也
  • Organizer: 第114回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 札幌市
• [Presentation] 温度刺激検査正常で、oVEMP, cVEMPのみが異常を呈するめまい症齢の検討 (2013)
  • Author(s): 岩﨑真一，牛尾宗貴，江上直也，藤本千里，木下淳，井上亜希，菅澤恵子，山岨達也
  • Organizer: 第114回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 札幌市
• [Presentation] Contribution of Vestibular Dysfunction to Postural Disorders in the Elderly (2013)
  • Author(s): Fujimoto C.
  • Organizer: 2nd Joint World Congress of ISPGR and Gait and Mental Function
  • Place of Presentation: Akita
  • Invited
• [Presentation] Three-dimensional analysis of postural control during stepping in patients with unilateral vestibular dysfunction (2013)
  • Author(s): Egami N, Iwasaki S, Fujimoto C, Yamasoba T.
  • Organizer: 2nd Joint World Congress of ISPGR and Gait and Mental Function
  • Place of Presentation: Akita
• [Presentation] 特発性両側前庭機能低下症例における前庭誘発筋電位の検討 (2013)
  • Author(s): 木下淳，岩崎真一，藤本千里，井上亜希，江上直也，牛尾宗貴，菅澤恵子，山岨達也
  • Organizer: 第72回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 大阪市
• [Presentation] トピックス（臨床セミナー）「EyeSeeCam®による定量的head impulse test －臨床－」 (2013)
  • Author(s): 牛尾宗貴，今井直子，石井阿弥子，村國朝子，江上直也，藤本千里，木下淳，鴨頭輝，菅澤恵子，岩崎真一，山岨達也
  • Organizer: 第72回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 大阪市
• [Presentation] モーションキャプチャーシステムを用いた聴神経腫瘍術後患者の体平衡障害についての検討 (2013)
  • Author(s): 江上直也，岩﨑真一，藤本千里，木下淳，牛尾宗貴，菅澤恵子，山岨達也
  • Organizer: 第72回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 大阪市
• [Presentation] めまいを伴う突発性難聴における末梢前庭機能の障害部位について (2013)
  • Author(s): 藤本千里，岩崎真一，江上直也，山岨達也
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: 宮崎市
• [Presentation] 経皮的ノイズ前庭電気刺激による体平衡機能改善の試み：両側末梢前庭障害患者における検討 (2013)
  • Author(s): 岩崎真一，木下淳，江上直也，藤本千里，牛尾宗貴，山岨達也
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: 宮崎市