Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Outline of Final Research Achievements |
The molecular mechanisms underlying perineural invasion (PNI)ーa characteristic pathological feature of adenoid cystic carcinoma (ACC)ーremain largely unclear. Recently, nerve growth factor (NGF) has been implicated in PNI in certain malignancies. Overexpression of Myb related to the MYB-NFIB fusion gene in ACC has also been correlated with PNI and survival. The aim of this study was to examine the expression of NGF together with its receptors, tropomyosin receptor kinase A (TrkA) and p75NRT, and Myb in ACC and assess their relationship with PNI and survival. NGF, TrkA, p75NRT, Myb, and MYB-NFIB fusion gene overexpression rates were 65%, 65%, 30%, 62%, and 45%, respectively. Pearson product-moment correlation coefficient revealed a strong correlation between NGF/TrkA immunostaining and PNI. Moreover, NGF overexpression was significantly associated with worse 8-year local control rate. However, p75NRT, Myb, and MYB-NFIB fusion gene expression was related to neither PNI nor survival.
|