Study of auditory cortex function and frequency map in mice using flavoprotein fluorescence imaging
Project/Area Number |
25861535
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 聴覚医学 / 聴覚中枢 / 耳鳴 / 聴覚 / 大脳聴覚野 / イメージング / 中枢性耳鳴 |
Outline of Final Research Achievements |
1)We studied mouse cerebral auditory cortex function by flavin protein fluorescence imaging method. In behavior experiments with the M shaped maze, the wild type mouses were able to select pairing learned figures only by presenting sound cues. Behavioral experiment proved that the mouse can acquire sound / figure associative memory. In addition, we found out in the mouse which acquired the association memory of sound / figure, that the auditory cortex dorsal area was active when only stimulated by the sound used for associative memory learning using the flavoprotein fluorescence imaging method. 2)We examined the difference in effect of masking pseudo tinnitus by white noise from headphones and speakers for normal hearing human. As a result, it was confirmed that the noise from the speaker that localizes the sound source far from the ear suppresses the pseudo tinnitus with a significantly small sound pressure.
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Report
(5 results)
Research Products
(8 results)
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[Presentation] The cortical area dorsally to auditory cortex involved in sound-shape association memory in mice2015
Author(s)
Tatsuya Yamagishi, Hiroaki Tsukano , Hironori Baba , Yuusuke Honma , Shinsuke Ohshima , Yamato Kubota , Kuniyuki Takahashi , Ryuichi Hishida , Takeshi Yagi , Katsuei Shibuki , Sugata Takahashi
Organizer
The 30th Politzer Society Meeting / 1st World Congress of Otology
Place of Presentation
TOKI MESSE Niigata
Year and Date
2015-06-30
Related Report
Int'l Joint Research
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[Presentation] Cortical depression in the mouse auditory cortex after sound discrimination learning2013
Author(s)
S.Ohshima, K.Takahashi, T.Yamagishi, H.Baba, Y.Honma, H.Tsukano, Y.Kubota, R.Hishida, K.Shibuki, S.Takahashi
Organizer
The 29th Politzer Society Meeting
Place of Presentation
Antalya, Turkey
Related Report