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Study of auditory cortex function and frequency map in mice using flavoprotein fluorescence imaging

Research Project

Project/Area Number 25861535
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

KUBOTA Yamato  新潟大学, 医歯学系, 助教 (40547593)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords聴覚医学 / 聴覚中枢 / 耳鳴 / 聴覚 / 大脳聴覚野 / イメージング / 中枢性耳鳴
Outline of Final Research Achievements

1)We studied mouse cerebral auditory cortex function by flavin protein fluorescence imaging method. In behavior experiments with the M shaped maze, the wild type mouses were able to select pairing learned figures only by presenting sound cues. Behavioral experiment proved that the mouse can acquire sound / figure associative memory. In addition, we found out in the mouse which acquired the association memory of sound / figure, that the auditory cortex dorsal area was active when only stimulated by the sound used for associative memory learning using the flavoprotein fluorescence imaging method.
2)We examined the difference in effect of masking pseudo tinnitus by white noise from headphones and speakers for normal hearing human. As a result, it was confirmed that the noise from the speaker that localizes the sound source far from the ear suppresses the pseudo tinnitus with a significantly small sound pressure.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice.2017

    • Author(s)
      1.Tsukano H, Horie M, Ohga S, Takahashi K, Kubota Y, Hishida R, Takebayashi H, Shibuki K
    • Journal Title

      Front Neural Circuits

      Volume: 11 Pages: 14-14

    • DOI

      10.3389/fncir.2017.00014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 耳近接音と遠方定位音による耳鳴マスキング効果の相違に関する検討2016

    • Author(s)
      窪田和、泉修司、大島伸介、森田由香、高橋邦行、堀井新
    • Organizer
      第26回日本耳科学会総会・学術講演会
    • Place of Presentation
      ホテル国際21(長野県長野市)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] The cortical area dorsally to auditory cortex involved in sound-shape association memory in mice2015

    • Author(s)
      Tatsuya Yamagishi, Hiroaki Tsukano , Hironori Baba , Yuusuke Honma , Shinsuke Ohshima , Yamato Kubota , Kuniyuki Takahashi , Ryuichi Hishida , Takeshi Yagi , Katsuei Shibuki , Sugata Takahashi
    • Organizer
      The 30th Politzer Society Meeting / 1st World Congress of Otology
    • Place of Presentation
      TOKI MESSE Niigata
    • Year and Date
      2015-06-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] OFF responses produced by short-term depression of thalamic inputs to inhibitory neurons in the mouse auditory cortex2015

    • Author(s)
      Hironori Baba, Hiroaki Tsukano, Tatsuya Yamagishi, Yuusuke Honma , Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Katsuei Shibuki, Sugata Takahashi
    • Organizer
      The 30th Politzer Society Meeting / 1st World Congress of Otology
    • Place of Presentation
      TOKI MESSE Niigata
    • Year and Date
      2015-06-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス聴覚・視覚連想記憶の行動学的解析2014

    • Author(s)
      山岸達也、塚野浩明、馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、高橋姿、澁木克栄
    • Organizer
      第59回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      下関市
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス聴覚・視覚連想記憶のM字迷路による解析2014

    • Author(s)
      山岸達也、塚野浩明、馬場洋徳、本間悠介、大島伸介、窪田和、高橋邦行、髙橋姿、澁木克栄
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Bilateral functional differences in the mouse auditory cortex using flavoprotein autofluoresence imaging2013

    • Author(s)
      K.Takahashi, H.Baba, Y.Honma, S.Ohshima, Y.Kubota, S.Takahashi
    • Organizer
      2nd Meeting of European Academy of ORL-HNS
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Research-status Report
  • [Presentation] Cortical depression in the mouse auditory cortex after sound discrimination learning2013

    • Author(s)
      S.Ohshima, K.Takahashi, T.Yamagishi, H.Baba, Y.Honma, H.Tsukano, Y.Kubota, R.Hishida, K.Shibuki, S.Takahashi
    • Organizer
      The 29th Politzer Society Meeting
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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