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The processing of dichotic listening in the mouse auditory cortex using flavoprotein fluorescence imaging

Research Project

Project/Area Number 25861536
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

OHSHIMA Shinsuke  新潟大学, 医歯学総合病院, 助教 (70632438)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords大脳聴覚野 / イメージング / マウス / 両耳分離補聴 / 聴覚リハビリ / 聴覚野 / フラビン蛋白蛍光イメージング / 視覚・聴覚連想記憶 / 分離補聴 / 周波数分解能 / フラビン蛋白
Outline of Final Research Achievements

In patients with sensorineural hearing loss "I hear sound but I do not understand the words", we feel the limit of traditional hearing aid treatment. We focused on the possibility of dichotic listening system for improving speech intelligibility and a new auditory rehabilitation that associates shape and sound, ie visual and auditory sense. Mouse cerebral auditory cortex responses were observed using flavoprotein autofluorescence imaging. Data collection of dichotic listening was technically difficult. After the mouse was exposed by associating visual and auditory stimuli, cerebral auditory cortex responses were found only by looking at the shape without sound. I think that these results can contribute to further new auditory rehabilitation using sensory stimulation other than hearing.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2017 2015 2014 Other

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 純音および複雑音刺激における視覚・聴覚連想記憶と連合野の解析2017

    • Author(s)
      小木学 山岸達矢 塚野浩明 西尾奈々 菱田竜一 堀井新 八木健 澁木克栄
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] The cortical area located dorsally to auditory cortex involved in sound-shape association memory in mice2015

    • Author(s)
      Tatsuya Yamagishi , Hiroaki Tsukano , Hironori Baba, Yuusuke Honma , Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki , Sugata Takahashi
    • Organizer
      The 30th Politzer Society Meeting
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] OFF responses produced by short-term depression of thalamic inputs to inhibitory neurons in the mouse auditory cortex2015

    • Author(s)
      Hironori Baba, Hiroaki Tsukano, Tatsuya Yamagish, Yuusuke Honma, Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Katsuei Shibuki, Sugata Takahashi
    • Organizer
      The 30th Politzer Society Meeting
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス聴覚・視覚連想記憶の行動学的解析2014

    • Author(s)
      山岸達矢、塚野浩明、馬場洋徳、本間悠介、大島伸介、窪田 和、髙橋邦行、山本 裕、髙橋 姿、澁木克栄
    • Organizer
      第59回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Cortical depression in the mouse auditory cortex after sound discrimination learning

    • Author(s)
      Shinsuke Ohshima, Kuniyuki Takahashi, Tatsuya Yamagishi, Hironori Baba, Yuusuke Honma, Hiroaki Tsukano, Yamato Kubota, Ryuichi Hishida, Katsuei Shibuki, Sugata Takahashi
    • Organizer
      29th politzer society meeting
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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