New treatment of head and neck cancer by normalization of tumor vasculature

• Project/Area Number: 25861538
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: Endo Kazuhira 金沢大学, 附属病院, 助教 (30547154)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: シスプラチン / ミセル / 頭頸部癌

Outline of Final Research Achievements

CDDP-incorporating polymeric micellar nanoparticle（NC-6004) have been developed and designed based on the idea that the drug delivery system (DDS) can accumulate in the tumor selectively, with reduced distribution in normal tissues and minimized undesirable side-effect.　We aimed to increase the anti-tumor effect through normalization of tumor vasculature. NC-6004 with TGF-β group decreased tumor volume of mice models compared with NC-6004 alone.

Research Products

• [Journal Article] Carnitine is associated with fatigue following chemoradiotherapy for head and neck cancer. (2015)
  • Author(s): Endo K, Tsuji A, Kondo S, Wakisaka N, Murono S, Yoshizaki T.
  • Journal Title: Acta Otolaryngol Volume: 45 Issue: 8 Pages: 244-247
  • DOI: 10.3109/00016489.2015.1030769
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) (2014)
  • Author(s): Takayoshi Ueno, Kazuhira Endo, Kiyomi Hori, Noriyuki Ozaki, Akira Tsuji, Satoru Kondo, Naohiro Wakisaka, Shigeyuki Murono, Kazunori Kataoka, Yasuki Kato, Tomokazu Yoshizaki
  • Journal Title: International Journal of Nanomedicine Volume: 9 Pages: 3005-12
  • DOI: 10.2147/ijn.s60564
  • Peer Reviewed / Open Access
• [Journal Article] Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma. (2012)
  • Author(s): Endo K, Ueno T, Kondo S, Wakisaka N, Murono S, Ito M, Kataoka K, Kato Y,Yoshizaki T
  • Journal Title: Cancer Sci. Epub Volume: 104 Issue: 3 Pages: 369-74
  • DOI: 10.1111/cas.12079
  • NAID: 120005830602
  • Peer Reviewed
• [Presentation] 新規ミセル化薬剤（ダハプラチン誘導体ミセル）の有用性 (2014)
  • Author(s): 上野貴雄、遠藤一平、辻亮、近藤悟、脇坂尚宏、室野重之、吉崎智一
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京(東京ファッションタウンビル）
  • Year and Date: 2014-06-13 – 2014-06-15
• [Presentation] Antitumor activity in oral squamous cell carcinoma of polymeric micelles (2014)
  • Author(s): Takayoshi Ueno, Kazuhira Endo, Tuji Akira, Satoru Kondo, Naohiro
  • Organizer: European Congress on Head and Neck Oncology
  • Place of Presentation: イギリス リバプール
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 頸部リンパ節転移に対する高分子ミセルを用いた薬物療法の検討 (2013)
  • Author(s): 遠藤一平、上野貴雄、辻亮、近藤悟、脇坂尚宏、室野重之、吉崎智一
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 京王プラザホテル（東京）