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Experimentally and clinically analysis of the symptoms with endolymphatic hydrops

Research Project

Project/Area Number 25861548
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionNagoya University

Principal Investigator

Yoshida Tadao  名古屋大学, 医学部附属病院, 助教 (90567017)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords内リンパ水腫 / メニエール病 / 内リンパ水腫モデルマウス
Outline of Final Research Achievements

This is the first investigation comparing EH in the inner ear between patients with MD and controls. This study showed that EH in the vestibule is a useful indicator of symptomatic definite MD, as EH in the vestibule was rare in the control population. Using our criteria, EH in the cochlea was common in the control patients. Most EH in the cochlea was bilateral, symmetric, and confirmed at the apical turn. The presence of EH in the cochlea may be a useful evaluation criterion along with hearing in MD because the EH in the cochlea was larger in advanced cases of hearing loss in MD patients.In our study, the presence of EH in the vestibule was a useful marker of symptomatic definite MD. EH in the apex of the cochlea was common in the control population, as shown in histopathological studies. The degree of EH in the cochlea was correlated with the hearing level and the progression of MD.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Patient with an SLC26A4 gene mutation who had low-frequency sensorineural hearing loss and endolymphatic hydrops2015

    • Author(s)
      Tadao Yoshida, Michihiko Sone, Shinji Naganawa, Tsutomu Nakashima
    • Journal Title

      J Laryngol Otol.

      Volume: 129(1) Issue: 1 Pages: 95-97

    • DOI

      10.1017/s0022215114003399

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in endolymphatic hydrops in patients with Meniere's disease treated conservatively for more than 1 year.2015

    • Author(s)
      Suga K, Kato M, Yoshida T, Nishio N, Nakada T, Sugiura S, Otake H, Kato K, Teranishi M, Sone M, Naganawa S, Nakashima T.
    • Journal Title

      Acta Otolaryngol.

      Volume: 135 Issue: 9 Pages: 866-870

    • DOI

      10.3109/00016489.2015.1015607

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops in superior canal dehiscence and large vestibular aqueduct syndromes.2015

    • Author(s)
      Sone M, Yoshida T, Morimoto K, Teranishi M, Nakashima T, Naganawa S.
    • Journal Title

      Laryngoscope.

      Volume: Nov 3 Issue: 6 Pages: 1446-1450

    • DOI

      10.1002/lary.25747

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic Resonance Imaging Evaluation of Endolymphatic Hydrops in Cases With Otosclerosis.2015

    • Author(s)
      Mukaida T, Sone M, Yoshida T, Kato K, Teranishi M, Naganawa S, Nakashima T.
    • Journal Title

      Otol. Neurotol.,

      Volume: 36 Issue: 7 Pages: 1146-1150

    • DOI

      10.1097/mao.0000000000000685

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ossicular Anomaly and Endolymphatic Hydrops as Risk Factors for Complications after Ossiculoplasty2015

    • Author(s)
      Norihiko Inagaki, Tadao Yoshida, Michihiko Sone, Satofumi Sugimoto, Hironao Otake, Masaaki Teranishi, Shinji Naganawa and Tsutomu Nakashima
    • Journal Title

      Austin Journal of Radiology

      Volume: 2 Pages: 1-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endolymphatic space size in patients with vestibular migraine and Meniere's disease.2014

    • Author(s)
      Nakada T, Yoshida T, Suga K, Kato M, Otake H, Kato K, Teranishi M, Sone M, Sugiura S, Kuno K, Pyykko I, Naganawa S, Watanabe H, Sobue G, Nakashima T.
    • Journal Title

      J Neurol.

      Volume: 261(11) Issue: 11 Pages: 2079-2084

    • DOI

      10.1007/s00415-014-7458-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetic Resonance Imaging Evaluation of Endolymphatic Hydrops in Cases with Otosclerosis.2014

    • Author(s)
      Mukaida T, Sone M, Yoshida T, Kato K, Teranishi M, Naganawa S, Nakashima T.
    • Journal Title

      Otol Neurotol.

      Volume: Dec.17

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections.2013

    • Author(s)
      IIDA Tatsuo, TERANISHI Masaaki, YOSHIDA Tadao, OTAKE Hironao, SONE Michihiko, KATO Masahiro, SHIMONO Mariko, YAMAZAKI Masahiro, NAGANAWA Shinji, NAKASHIMA Tsutomu
    • Journal Title

      Acta Otolaryngol

      Volume: 133 Issue: 5 Pages: 434-438

    • DOI

      10.3109/00016489.2012.753640

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops in patients with tinnitus as the major symptom.2013

    • Author(s)
      Tadao Yoshida, Masaaki Teranishi, Masahiro Kato, Hironao Otake, Ken Kato, Michihiko Sone, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima
    • Journal Title

      Eur Arch Otorhinolaryngol.

      Volume: 270(12) Issue: 12 Pages: 3043-3048

    • DOI

      10.1007/s00405-013-2380-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops.2013

    • Author(s)
      Pyykko I
    • Journal Title

      BMJ Open.

      Volume: 3 Issue: 2 Pages: 1-10

    • DOI

      10.1136/bmjopen-2012-001555

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss.2013

    • Author(s)
      Mariko Shimono, Masaaki Teranishi, Tadao Yoshida, Masahiro Kato, Rui Sano, Hironao Otake, Ken Kato, Michihiko Sone, Naoki Ohmiya, Shinji Naganawa, Tsutomu Nakashima
    • Journal Title

      Otol Neurotol.

      Volume: 34(7) Issue: 7 Pages: 1241-1246

    • DOI

      10.1097/mao.0b013e3182990e81

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endolymphatic Hydrops in Meniere’s disease and Meniere-related Symptoms2013

    • Author(s)
      吉田 忠雄、中島 務
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 106 Issue: 10 Pages: 861-870

    • DOI

      10.5631/jibirin.106.861

    • NAID

      10031200168

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2013 Research-status Report
  • [Journal Article] MRI evaluation of the bilateral endolymphatic space in patients with unilateral Meniere's disease2013

    • Author(s)
      吉田忠雄、加藤正大、大竹宏直、加藤健、寺西正明、片山直美、中島務
    • Journal Title

      Equilibrium Research

      Volume: 72 Issue: 4 Pages: 247-253

    • DOI

      10.3757/jser.72.247

    • NAID

      10031194225

    • ISSN
      0385-5716, 1882-577X
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Endolymphatic space in Meniere’s and non-otological diseases2015

    • Author(s)
      Tadao Yoshida, Michihiko Sone, Kyoko Morimoto, Takafumi Nakada, Shinji Naganawa & Tsutomu Nakashima
    • Organizer
      7th International Symposium on Meniere's Disease and Inner Ear Disorders
    • Place of Presentation
      Roma(Italy)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A reappraisal of Meniere’s disease supported by variable latency of symptoms and MRI visualization of the endolymphatic hydrops2015

    • Author(s)
      Tadao Yoshida, Ilmari Pyykko, Tsutomu Nakashima, Jing Zou, Shinji Naganawa
    • Organizer
      7th International Symposium on Meniere's Disease and Inner Ear Disorders
    • Place of Presentation
      Rome(Italy)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メニエール病と非耳疾患症例の内リンパ腔画像評価2015

    • Author(s)
      吉田 忠雄、大竹 宏直 寺西 正明、曾根 三千彦、長縄 慎二
    • Organizer
      第25回日本耳科学会総会 学術講演会
    • Place of Presentation
      長崎県長崎市 長崎ブリックホール
    • Year and Date
      2015-10-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Endolymphatic space in Meniere’s and non-otological diseases2015

    • Author(s)
      Tadao Yoshida, Michihiko Sone, Kyoko Morimoto, Takafumi Nakada, Shinji Naganawa & Tsutomu Nakashima
    • Organizer
      AAO-HNSF Annual meeting 2015
    • Place of Presentation
      Dallas(USA)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低音障害型感音難聴に内リンパ水腫を伴ったSLC26A4遺伝子変異症例2015

    • Author(s)
      吉田 忠雄、曾根 三千彦、寺西 正明、大竹 宏直、中島 務
    • Organizer
      第77回耳鼻咽喉科臨床学会総会・学術講演会
    • Place of Presentation
      静岡県浜松市 オークラアクトシティホテル浜松
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 耳鳴と内リンパ水腫画像評価

    • Author(s)
      吉田 忠雄
    • Organizer
      愛知県難聴・耳鳴に関する懇話会
    • Place of Presentation
      エーザイホール(名古屋)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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