Experimentally and clinically analysis of the symptoms with endolymphatic hydrops
| Project/Area Number |
25861548
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya University |
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Principal Investigator |
Yoshida Tadao 名古屋大学, 医学部附属病院, 助教 (90567017)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 内リンパ水腫 / メニエール病 / 内リンパ水腫モデルマウス |
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| Outline of Final Research Achievements |
This is the first investigation comparing EH in the inner ear between patients with MD and controls. This study showed that EH in the vestibule is a useful indicator of symptomatic definite MD, as EH in the vestibule was rare in the control population. Using our criteria, EH in the cochlea was common in the control patients. Most EH in the cochlea was bilateral, symmetric, and confirmed at the apical turn. The presence of EH in the cochlea may be a useful evaluation criterion along with hearing in MD because the EH in the cochlea was larger in advanced cases of hearing loss in MD patients.In our study, the presence of EH in the vestibule was a useful marker of symptomatic definite MD. EH in the apex of the cochlea was common in the control population, as shown in histopathological studies. The degree of EH in the cochlea was correlated with the hearing level and the progression of MD.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Changes in endolymphatic hydrops in patients with Meniere's disease treated conservatively for more than 1 year.2015
Author(s)
Suga K, Kato M, Yoshida T, Nishio N, Nakada T, Sugiura S, Otake H, Kato K, Teranishi M, Sone M, Naganawa S, Nakashima T.
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Journal Title
Acta Otolaryngol.
Volume: 135
Issue: 9
Pages: 866-870
DOI
Related Report
Peer Reviewed
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[Journal Article] Endolymphatic space size in patients with vestibular migraine and Meniere's disease.2014
Author(s)
Nakada T, Yoshida T, Suga K, Kato M, Otake H, Kato K, Teranishi M, Sone M, Sugiura S, Kuno K, Pyykko I, Naganawa S, Watanabe H, Sobue G, Nakashima T.
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Journal Title
J Neurol.
Volume: 261(11)
Issue: 11
Pages: 2079-2084
DOI
Related Report
Peer Reviewed
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[Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss.2013
Author(s)
Mariko Shimono, Masaaki Teranishi, Tadao Yoshida, Masahiro Kato, Rui Sano, Hironao Otake, Ken Kato, Michihiko Sone, Naoki Ohmiya, Shinji Naganawa, Tsutomu Nakashima
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Journal Title
Otol Neurotol.
Volume: 34(7)
Issue: 7
Pages: 1241-1246
DOI
Related Report
Peer Reviewed
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