| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Previous studies in animals and humans have demonstrated the efficacy of insulin-like growth factor-1 (IGF-1) for hearing recovery in acute hearing loss. In the present study, we focus on regeneration of the synapse between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) as a mechanism of hearing recovery following IGF-1 application. To test the capability of IGF-1 for promoting regeneration of IHC-SGN synapses, an ex vivo model of excitotoxicity was employed. In cochlear explants, IGF-1 promoted IHC-SGN regeneration after excitotoxic insult via the phosphoinositide 3-kinase-Akt signaling pathway. These results demonstrated that IGF-1 promoted regeneration of IHC-SGN synapses, which may be involved in mechanisms of hearing recovery following IGF-1 treatment.
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