Involvement of Wnt-pathway in aging-related inner ear dysfunction
| Project/Area Number |
25861556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
Morihana Tetsuo 大阪大学, 医学(系)研究科(研究院), 助教 (80634170)
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| Research Collaborator |
花田 有紀子 大阪大学大学院医学系研究科, 耳鼻咽喉科・頭頸部外科学
滝本 泰光 大阪大学大学院医学系研究科, 神経細胞生物学
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 加齢 / 難聴 / 前庭機能 / ウイント / 内耳障害 / 前庭動眼反射 / 聴覚 / 平衡覚 / 高齢 / Wnt経路 / C1q / 加齢性 / 平衡障害 / Wnt |
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| Outline of Final Research Achievements |
We made a hypothesis that Wnt pathway plays any roles in aging-related inner ear dysfunction. Little expression of wnt-related genes was detected in aged WT mice. Using C1q-deficient mice, hearing and balance functions were simultaneously evaluated using ABR and COR devices. Although our hypothesis was denied from the results, the availability of simultaneous evaluation of both ABR and VOR in mice was shown.
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Report
(4 results)
Research Products
(1 results)
