| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
66% of peripheral blood mononuclear cells (PBMCs) from patients with Japanese cedar pollinosis produced IL-31 in response to Cry j 1, the major allergen molecule in Japanese cedar pollen. Symptom score and QOL score were significantly higher in patients with positive IL-31 production than those with negative production. IL-31 production by PMBCs were significantly increased following the exposure to IL-2 and IL-33. On the other hand, no induction of IL-31 production was seen in innate lymphoid cells in PBMCs. These results suggest that main IL-31 producing cell in PBMCs was CD4 positive T cells, and the cells are involved in the exacerbation of allergic rhinitis.
|
