| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, we investigated the protective effect of 18 supplements,and 8 herbal medicine against hair cell degeneration induced by neomycin using zebrafish lateral hair cells damage model. We found that 3 supplements and all of 8 herbal medicine protects sensory hair cells against neomycin-induced death in zebrafish lateral cell lines. In addition, we confirmed the protective effect of screened drugs against noise-induced hearing loss in guinea pigs. These results show that screened drugs can be useful as a protective drug in the inner ear.
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