New therapuitic strategy based on functional analysis of antigen presenting cell in the Lymphoepithelium of Pediatric Adenoids via druo delivary system.
| Project/Area Number |
25861574
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 上皮細胞 / RSV / 宿主免疫応答 / 自然免疫 / 宿主応答 / RSウイルス感染症 / 小児 / 上皮 / 小児咽頭扁桃 / ウイルス / microRNA |
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| Outline of Final Research Achievements |
Nose- or nasopharynx-associated lymphoid tissue (NALT) has a unique role that is distinct from that of other lymphoid tissues. During upper airway mucosal immune response, NALT induces a variety of responses, including cytokine and chemokine production and innate immune response, to establish acquired immunity. NALT consists of epithelial cells, epithelium-associated lymphoid tissues such as IgA-committed B cells, innate lymphocytes, T helper cells and dendritic cells. Intranasal immunization has recently been shown to effectively induce a proactive immune response in the local mucosa in addition to a systemic immune response. We provide evidence suggesting that upper airway epitheium as a component of NALT in children may play an important role in inducing innate immunity following viral infection.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] 扁桃・アデノイドはなぜあるのか?鼻はなにをしているのか? 小児の粘膜免疫・粘膜防御最前線2013
Author(s)
氷見 徹夫, 高野 賢一, 山下 恵司, 小笠原 徳子, 正木 智之, 小幡 和史, 堤 裕幸, 小島 隆, 一宮 慎吾, 澤田 典均, 横田 伸一
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Journal Title
小児耳鼻咽喉科
Volume: 34
Pages: 239-244
NAID
Related Report
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