Mechanisms of inflammsomes activation in human tonsil

• Project/Area Number: 25861575
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Sapporo Medical University
• Principal Investigator: TAKANO Kenichi 札幌医科大学, 医学部, 講師 (70404689)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口蓋扁桃 / 扁桃癌 / インフラマソーム / ヒト扁桃疾患

Outline of Final Research Achievements

We found strong expression of NLRP3, ASC, IL-1β, IL-18, and Caspase-1 in human oropharyngeal SCC, while weak or no expression of these proteins in normal tonsil. We also found that the distribution of MIB-1 was not significantly different from inflammasome-associated proteins in oropharyngeal SCC, and that no correlation of the expression of inflammasome-associated proteins and HPV infection. These findings suggest that inflammasomes in oropharyngeal SCC have a key role through facilitating antitumor immunity, and the possibility of new roles for inflammasomes in oropharynx may exist.

Research Products

• [Journal Article] Tracheo-innominate artery fistula with severe motor and intellectual disability: incidence and therapeutic management. (2014)
  • Author(s): Kurose M, Takano K, Mitsuzawa H, Himi T
  • Journal Title: Int J Pediatr Otorhinolaryngol Volume: 78 Issue: 8 Pages: 1348-1351
  • DOI: 10.1016/j.ijporl.2014.05.027
  • Peer Reviewed
• [Journal Article] The clinical characteristics of patients with IgG4-related disease with infiltration of the labial salivary gland by IgG4-positive cells (2014)
  • Author(s): Abe A, Takano K, Seki N, Himi T. (7名7番)
  • Journal Title: Mod Rheumatol Volume: 26 Issue: 6 Pages: 949-952
  • DOI: 10.3109/14397595.2014.891964
  • URL: http://informahealthcare.com/doi/abs/
  • Peer Reviewed
• [Journal Article] Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment. (2014)
  • Author(s): Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
  • Journal Title: Rheumatology Volume: 54 Issue: 1 Pages: 45-49
  • DOI: 10.1093/rheumatology/keu228
  • Peer Reviewed / Open Access
• [Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database. (2014)
  • Author(s): Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
  • Journal Title: Mod Rheumatol Volume: 27 Issue: 2 Pages: 1-6
  • DOI: 10.3109/14397595.2014.950036
  • Peer Reviewed
• [Journal Article] The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease (2014)
  • Author(s): Tabeya T, Seki N, Takano K, Himi T, (12名10番)
  • Journal Title: Mod Rheumatol Volume: 4 Issue: 6 Pages: 953-960
  • DOI: 10.3109/14397595.2014.882045
  • Peer Reviewed
• [Journal Article] Role of tight junctions in signal transduction: an update. (2014)
  • Author(s): Takano K, Kojima T, Sawada N, Himi T
  • Journal Title: EXCLI Journal Volume: 13 Pages: 1145-1162
  • Peer Reviewed
• [Journal Article] Takano K, Yajima R, Seki N, Abe A, Yamamoto M, Takahashi H, Himi T. A study of infraorbital nerve swelling associated with immunoglobulin G4 Mikulicz's disease (2014)
  • Author(s): Takano K, Yajima R, Seki N, Abe A, Yamamoto M, Takahashi H, Himi T
  • Journal Title: Mod Rheumatol Volume: 24 Issue: 5 Pages: 798-801
  • DOI: 10.3109/14397595.2013.865884
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells (2014)
  • Author(s): Nomura K, Takano K, Himi T, Kojima T. (10名, 9, 10番)
  • Journal Title: Respir Res Volume: 18 Issue: 1 Pages: 15-21
  • DOI: 10.1186/1465-9921-15-21
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of tight junctions in upper airway epithelium (2013)
  • Author(s): Kojima T, Takano K, Himi T(全19名1, 3, 18番)
  • Journal Title: Biomed Res Int Volume: 2013 Pages: 947072-947072
  • DOI: 10.1155/2013/947072
  • Peer Reviewed
• [Journal Article] Collision tumor of the thyroid: follicular carcinoma plus papillary carcinoma plus adenomatous goiter (2013)
  • Author(s): Takano K, Kikuchi K, Matsumiya H, Himi T
  • Journal Title: World J Med Surg Case Rep Volume: 2 Pages: 21-25
  • Peer Reviewed
• [Presentation] Primary cilia in temperature-sensitive mouse cochlear precursor hair cells (2014)
  • Author(s): Takano K, Kojima T, Kakuki T, Miyata R, Kohno T, Kaneko Y, Himi T
  • Organizer: Inner Ear Biology Workshop 2014 in Kyoto
  • Place of Presentation: 京都
  • Year and Date: 2014-11-01 – 2014-11-04
• [Presentation] IgG4関連疾患における鼻副鼻腔病変の検討 (2014)
  • Author(s): 高野賢一，矢島諒人，関 伸彦，大國 毅，氷見徹夫
  • Organizer: 第53回日本鼻科学会総会・学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Respiratory Syncytial Virus Infection of Human Nasal Epithelial Cells (2014)
  • Author(s): Takano K, Okuni T, Ogasawara N, Obata K, Nomura K, Kojima T, Himi T
  • Organizer: ERS/ISIAN 2014
  • Place of Presentation: アムステルダム
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] The nasal epithelial barrier function: recent progress in research and development (2013)
  • Author(s): Takano K, Himi T
  • Organizer: 16th Asian Research Symposium in Rhinology
  • Place of Presentation: Tokyo
• [Presentation] Inflammasomes in Oropharyngeal cancer. (2013)
  • Author(s): Takano K, Ogasawara N, Nomura K, Abe A, Himi T
  • Organizer: The 8th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
  • Place of Presentation: Zurich
• [Book] 耳鼻咽喉科・頭頸部外科86（１）：IgG4関連疾患の診断と治療 (2014)
  • Author(s): 高野賢一, 関 伸彦, 阿部 亜由美, 矢島諒人, 氷見徹夫
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] JOHNS (2013)
  • Author(s): 高野賢一，氷見徹夫
  • Total Pages: 3
  • Publisher: 東京医学社
• [Book] アレルギー・免疫 (2013)
  • Author(s): 高野賢一，亀倉隆太，小島隆，郷 充，澤田均典，氷見徹夫
  • Total Pages: 9
  • Publisher: 医学ジャーナル社