Mechanisms of inflammsomes activation in human tonsil
Project/Area Number |
25861575
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 口蓋扁桃 / 扁桃癌 / インフラマソーム / ヒト扁桃疾患 |
Outline of Final Research Achievements |
We found strong expression of NLRP3, ASC, IL-1β, IL-18, and Caspase-1 in human oropharyngeal SCC, while weak or no expression of these proteins in normal tonsil. We also found that the distribution of MIB-1 was not significantly different from inflammasome-associated proteins in oropharyngeal SCC, and that no correlation of the expression of inflammasome-associated proteins and HPV infection. These findings suggest that inflammasomes in oropharyngeal SCC have a key role through facilitating antitumor immunity, and the possibility of new roles for inflammasomes in oropharynx may exist.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment.2014
Author(s)
Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
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Journal Title
Rheumatology
Volume: 54
Issue: 1
Pages: 45-49
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database.2014
Author(s)
Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
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Journal Title
Mod Rheumatol
Volume: 27
Issue: 2
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Takano K, Yajima R, Seki N, Abe A, Yamamoto M, Takahashi H, Himi T. A study of infraorbital nerve swelling associated with immunoglobulin G4 Mikulicz's disease2014
Author(s)
Takano K, Yajima R, Seki N, Abe A, Yamamoto M, Takahashi H, Himi T
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Journal Title
Mod Rheumatol
Volume: 24
Issue: 5
Pages: 798-801
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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