Development of a novel treatment for head and neck cancer using telomerase-specific adenovirus
| Project/Area Number |
25861577
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SAKAKIBARA Atsuko 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (10636533)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 頭頸部扁平上皮癌 / テロメラーゼ / ウイルス治療 / 放射線感受性 / テロメライシン / ウイルス療法 |
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| Outline of Final Research Achievements |
This study evaluated the efficacy of combination treatment with OBP-301, a telomerase-specific replication-selective adenovirus, and radiotherapy in overcoming radioresistance by examining its effect on radiation-resistant head and neck squamous cell carcinoma (HNSCC) cells. Radiation-resistant HNSCC cells were treated with OBP-301 and radiation in vitro and in an orthotopic nude mouse model in vivo. Infection with OBP-301 was found to enhance the antitumor efficacy of radiation both in vitro and in vivo by inhibiting expression of MRN complex, which plays a key role in DNA repair machinery and increasing apoptosis induction. Combined OBP-301 and radiation therapy may thus be a novel therapeutic strategy for treating HNSCC.
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Report
(3 results)
Research Products
(2 results)
