| Project/Area Number |
25861585
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
GEN Sugita 和歌山県立医科大学, 医学部, 博士研究員 (20407274)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | microbiota / 群集構造解析 / 中耳貯留液 / 16SrRNA遺伝子 / 鼻咽腔細菌叢 / 中耳細菌叢 |
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| Outline of Final Research Achievements |
Results: In the nasopharynx, coexisting with causative pathogens and commensal consist bacterial flora, recentaly nominated as nasopharyneal microbiota. The microbiome in the nasopharynx will be dramatically changed during the course of antimicrobial treatments, vaccination and acute phase of upper respiratory inflammation.
Conclusion: Our previous study revealed the dramatic changes in the nasopharyngeal pneumococcal density during the course of upper respiratory infections. In this study, despite an abundance of data on incidence, prevalence and density of potential pathogens in NP microbiota of children and adults, the detailed composition of the NP microbial community, both during health and disease have not been studied. We, therefore, will discuss microbita in the nasopharynx for better understanding the change of nasopharyngeal bacterial flora during various infectious situations.
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