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Immunological features in the patients with recurrent eosinophilic chronic rhinosinusitis

Research Project

Project/Area Number 25861586
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionJikei University School of Medicine

Principal Investigator

NAKAYAMA Tsuguhisa  東京慈恵会医科大学, 医学部, 助教 (50408431)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords好酸球性副鼻腔炎 / 内視鏡下鼻内手術 / 一酸化窒素 / 慢性副鼻腔炎 / 好酸球
Outline of Final Research Achievements

Eosinophilic chronic rhinosinusitis has a tendency of recurrence after the surgery. We classified the patients who had the surgery as good prognosis group, steroid effectiveness group, and steroid resistance group. In steroid resistance group, mucosal eosinophil count and IL-5 mRNA tended to higher, but significantly difference. In addition, the measurement of nasal FeNO may be an effective tool that assess the sinus mucosa condition during postoperative period.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 2 results)

  • [Journal Article] Endoscopic single-handed septoplasty with batten graft for caudal septum deviation2014

    • Author(s)
      Nakayama T, Okushi T, Yamakawa S, Kuboki A, Haruna S
    • Journal Title

      Auris Nasus Larynx

      Volume: 41 Issue: 5 Pages: 441-5

    • DOI

      10.1016/j.anl.2014.05.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic modified medial maxillectomy for odontogenic cysts and tumors2014

    • Author(s)
      Nakayama T, Otori N, Asaka D, Okushi T, Haruna S
    • Journal Title

      Rhinology

      Volume: 52 Issue: 4 Pages: 376-80

    • DOI

      10.4193/rhino13.134

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Nasal fraction exhaled nitric oxide in chronic rhinosinusitis2014

    • Author(s)
      Nakayama T, Kanaya H, Yamakawa S, Kuboki A, Haruna S
    • Organizer
      ISIAN-IRS-PARS 2014
    • Place of Presentation
      Dubai
    • Year and Date
      2014-11-20 – 2014-11-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Advanced ESS進化する鼻科内視鏡手術 Rhinologistにのっての下垂体手術 鼻中隔・外鼻形成術2014

    • Author(s)
      中山次久
    • Organizer
      第53回日本鼻科学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 上顎洞内反性乳頭腫に対するEndoscopic modified medial maxillectomy2014

    • Author(s)
      中山次久、浅香大也、大櫛哲史、久保木章仁、松脇由典、小島博己、鴻信義
    • Organizer
      第115回日本耳鼻咽喉科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Where are we in Pathophysiology of Chronic Rhinosinusitis? - Fungus -2014

    • Author(s)
      Nakayama T
    • Organizer
      15th Korea-Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Seoul
    • Year and Date
      2014-04-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 慢性副鼻腔炎術後における鼻呼気NO測定の意義2013

    • Author(s)
      中山次久
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2023-03-16  

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