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Expression of stem cell markers Oct3/4 and Nanog and its clinical significance in oral tongue squamous cell carcinoma

Research Project

Project/Area Number 25861587
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

HABU NOBORU  慶應義塾大学, 医学部(信濃町), 共同研究員 (60365369)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌 / 転移
Outline of Final Research Achievements

In the present study, we aimed to determine the CSC markers in the SP of HNSCC cells along with their functions in cellular behaviors, and to clarify the association of these markers with delayed neck metastasis (DNM).Results: SP were isolated in cell lines examined. Expression levels of Oct3/4 and Nanog were higher in SP cells than MP cells. Additionally, cell migration and invasion abilities were higher in SP cells than MP cells, whereas there was no difference in proliferation. Univariate analysis showed that Expression of Oct3/4 and Nanog, vascular and muscular invasion, and mode of invasion were significantly correlated with DNM. Multivariate logistic regression revealed that Oct3/4 expression and vascular invasion were independently predictive of DNM.Conclusion: These results suggest that Oct3/4 and Nanog represent probable CSC markers in HNSCC, which contribute to the development of DNM in part by enhancing cell motility and invasiveness.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delyaed neck metastasis in stageⅠ/Ⅱ oral tongue squamous cell carcinoma2015

    • Author(s)
      Noboru Habu
    • Journal Title

      BMC cancer

      Volume: 18 Issue: 1 Pages: 730-730

    • DOI

      10.1186/s12885-015-1732-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Expression of stem cell markers Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II tongue squamous cell carcinoma2016

    • Author(s)
      Noboru Habu
    • Organizer
      2016 American associated Cancer Research
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of stem cell markers Oct3/4 and Nanog and its clinical implication for delayed neck metastasis in tongue carcinoma2015

    • Author(s)
      Noboru Habu
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌における癌幹細胞様細胞の存在とmarkerの発現に関する検討2013

    • Author(s)
      羽生昇
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌における癌幹細胞様細胞マーカーの発現とその臨床的意義に関する検討2013

    • Author(s)
      羽生昇
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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