| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Recurrence of cholesteatoma is mainly caused by poor mucosal regeneration in the middle ear cavity and mastoid cavity, and changes such as granulation tissue formation can occur, which impair gaseous exchange in the middle ear cavity. If middle ear mucosa can be preserved and the rapid postoperative regeneration of mucosa on the exposed bone surface can be achieved after middle ear surgery, surgical treatment for otitis media including cholesteatoma can be potentially improved. I developed a novel method combining canal wall up tympanoplasty and autologous nasal mucosal epithelial cell sheet transplantation for postoperative regeneration of the middle ear mucosa. I validated the safety and efficacy of human nasal mucosal epithelial cell sheets for use in clinical trials.
I have started clinical trial and performed this procedure on five patients with middle ear cholesteatoma. All patients showed a favorable postoperative course, with no adverse events or complications.
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