| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Stomatitis model was created by contacting the acetic acid-containing filter paper in the oral mucosa of oxytocin-mRFP1 transgenic rats, and the activation of oxytocin neurons localized in the hypothalamic supraoptic and paraventricular nuclei (PVN) was quantified by mRFP1 red fluorescent intensity as changes of the expression of the oxytocin gene. In stomatitis model group, mRFP1 red fluorescent intensity in the parvocellular and magnocellular divisions of the PVN has been increased significantly in comparison with control group. This result suggests that stomatitis-induced nociceptive stimulation may cause activation of oxytocin neurons in the PVN. Further study should examine whether hypothalamic oxytocinergic pathways may be involved in regulation of pain in head and neck during inflammation and cancer.
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