| Project/Area Number |
25861608
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | シェアストレス / 網膜血管内皮 / 網膜血流 / 糖尿病網膜症 / 糖尿病黄斑浮腫 / タイトジャンクション / 血管内皮機能 |
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| Outline of Final Research Achievements |
Vascular endothelium responds to shear stress generated by blood flow and changes their functions. We examined the effect of 'low' shear stress especially in retinal low perfusion, and reported that low shear stress caused up-regulation of proinflammatory genes in human retinal microvascular endothelial cells (HRMECs). Moreover we also showed that relatively high shear stress in phisiological retinal circulation increased the expression of ZO-1, which is the tight-junction protein, compared to the relative low shear stress and static condition in HRMECs. On the other hand, we performed several clinical studies about the pathogenesis of diabetic macular edema (DME), and demonstrated that endothelial dysfunction was observed in the patients with DME, and the DME with serous retinal detachment was correlated with chronic kidney disease. Choroidal vascular disorder was also observed in diabetic patients receiving hemodyalisis.
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