| Project/Area Number |
25861609
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病網膜症 / 虚血性網膜症 / 神経保護 / 血管保護 / 分散ヘスペレチン / 糖転移ヘスペリジン |
|---|
| Outline of Final Research Achievements |
The present study for the first time demonstrated that water-dispersible hesperetin (WD-Hpt) decreased the number of cell death in the ganglion cell layer after ischemia reperfusion (I/R) injury in the retina. This beneficial protective effect of WD-Hpt on the retina derived from reduction of oxidative stress. Consequently, this led to alleviation of activated microglia and reduction of chronic inflammation. Therefore, WD-Hpt is likely to protect neural cells in the retina from diabetes by reducing oxidative stress and chronic inflammation. Moreover, WD-Hpt was shown to reduce I/R-induced gliosis in Muller cells. This also indicates that WD-Hpt can be used for the treatment in diabetic macular edema.
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