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Evaluation of new treatments for retinitis pigmenosa using indicators of oxidative stress

Research Project

Project/Area Number 25861610
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionHirosaki University

Principal Investigator

ITO Tadashi  弘前大学, 医学(系)研究科(研究院), その他 (00431453)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords酸化ストレス / 抗酸化力 / 網膜硝子体疾患 / 網膜色素変性 / 網膜剥離 / 糖尿病網膜症 / 網膜静脈閉塞症 / 網膜上膜 / 黄斑円孔 / フリーラジカル
Outline of Final Research Achievements

Retina is always illuminated by light, and light accelerates photoreceptor damage through oxidative damage. Retinitis pigmentosa (RP) that is primarily caused by one of photoreceptor-specific genes has been known to be influenced by light-induced oxidative damage. Therefore, a new treatment for RP using oxidative stress indicators may be effective as a new monitoring method. In this study, in order to establish a new treatment for RP using oxidative stress as an indicator, basic studies for evaluating intraocular oxidative stress and antioxidant potential in samples from patients with various vitreoretinal disorders. The aim of this study is whether or not the results from this study can be applied to the field of the research for RP.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] プロピルチオウラシルにより両球後視神経炎を生じたANCA関連血管炎の1例2013

    • Author(s)
      工藤孝志、鈴木 香、鈴木幸彦、工藤朝香、木村智美、伊藤 忠、片山君予、中澤 満
    • Journal Title

      臨床眼科

      Volume: 67 Pages: 209-213

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: An extended study.2013

    • Author(s)
      Nakazawa M, Suzuki Y, Ito T, Metoki T, Kudo T, Ohguro H.
    • Journal Title

      BoMed Research International

      Volume: 2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ICE症候群に対して硝子体、緑内障インプラント、角膜移植同時手術を施行した1例2014

    • Author(s)
      伊藤 忠、工藤孝志、吹田淑子、毛内奈津姫、中澤 満
    • Organizer
      第126回青森眼科集談会
    • Place of Presentation
      弘前大学医学部コミュニケーションセンター
    • Year and Date
      2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] シリコーンオイル抜去を目的とした硝子体手術の成績2014

    • Author(s)
      陳内嘉浩、鈴木幸彦、伊藤 忠、中澤 満
    • Organizer
      第126回青森眼科集談会
    • Place of Presentation
      弘前大学医学部コミュニケーションセンター
    • Year and Date
      2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ICE症候群に対して硝子体、緑内障インプラント、角膜移植同時手術を施行した1例2014

    • Author(s)
      伊藤 忠、工藤孝志、吹田淑子、毛内奈津姫、中澤 満
    • Organizer
      第118回日本眼科学会
    • Place of Presentation
      東京国際フォーラム、帝国ホテル
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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