Effect of intraoperative trehalose in trabeculectomy using rabbit eyes

Research Project

Project/Area Number	25861615
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	University of Tsukuba
Principal Investigator	OKAMOTO YOSHIFUMI 筑波大学, 医学医療系, 講師 (00537219)
Research Collaborator	HOSHI Sujin
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords	トレハロース / 癒着防止 / 緑内障 / 眼科 / 結膜瘢痕の経時変化 / 緑内障手術
Outline of Final Research Achievements	This study was conducted to examine the effect of trehalose for anti-fibrosis in rabbit eyes undergoing trabeculectomy. No significant inflammation and infection were observed in both trehalose and control group with slit-lamp examination. With anterior segment polarization-sensitive optical coherence tomography, increase of phase retardation was shown around the bleb in trehalose group. The present result indicates that intraoperative use of trehalose may inhibit the formation of postoperative adhesion around the conjunctiva and sclera.

Report

(3 results)