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Development of molecular targeted therapy for HTLV-1 uveitis

Research Project

Project/Area Number 25861621
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kamoi Koju  東京医科歯科大学, 医学部附属病院, 講師 (40451942)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsHTLV-1 ぶどう膜 / 眼内炎症 / レトロウイウルス / ぶどう膜炎 / HTLV-1ぶどう膜炎 / レトロウイルス / 眼炎症 / HTLV-1 / 分子標的治療
Outline of Final Research Achievements

For development of the molecular targeted therapy for HTLV-1 uveits, this study investigated the effect of HTLV-1 infected cells on ocular tissues. As the blood-retinal barrier is formed at retinal pigment epithelium (RPE) cell layer, the inflammatory change that caused by the contact between HTLV-1 infected cells and the retinal epithelium (RPE) cells were investigated. It was revealed that the contact could significantly increase the protein level of inflammatory cytokines and chemokines (IL-6, IL-8, MCP-1, RANTES).
Uveitic glaucoma is a common complication of HTLV-1 uveitis, therefore it is possible that HTLV-1 infected T-cells could have had an effect on the trabecular meshwork. Trough the investigation, the same tendency was seen in the production of inflammatory cytokines and chemokines in the contact between HTLV-1 infected cells and trabecular meshwork.This study revealed key molecular targets to suppress intraocular inflammation caused by HTLV-1.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (41 results)

All 2016 2015 2014 2013 Other

All Journal Article (15 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (23 results) (of which Int'l Joint Research: 1 results) Book (3 results)

  • [Journal Article] Formation of Segmental Rounded Nodules During Infiltration of Adult T-Cell Leukemia Cells Into the Ocular Mucous Membrane.2016

    • Author(s)
      Kamoi K, Nagata Y, Mochizuki M, Kobayashi D, Ohno N, Uchimaru K, Tojo A, Ohno-Matsui K.
    • Journal Title

      Cornea

      Volume: 35 Issue: 1 Pages: 137-139

    • DOI

      10.1097/ico.0000000000000689

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 感染性眼内炎2016

    • Author(s)
      鴨居功樹
    • Journal Title

      眼科.

      Volume: 58 Pages: 301-306

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 眼炎症疾患における診療の進歩.2016

    • Author(s)
      鴨居功樹, 大野京子.
    • Journal Title

      日本医事新報.

      Volume: 4789 Pages: 57-57

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 東京医科歯科大学眼科におけるぶどう膜炎臨床統計―1998年~2001年と2007年~2011年の比較2015

    • Author(s)
      宮永 将, 高瀬 博, 川口 龍史, 鴨居 功樹, 清水 健太郎, 横田 眞子, 杉田 直, 望月 學.
    • Journal Title

      日本眼科学会雑誌

      Volume: 119 Pages: 678-685

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 造血器悪性疾患に合併した眼底病変に対する包括的感染症PCRの有用性2015

    • Author(s)
      尾碕 憲子, 川口 龍史, 村上 喜三雄, 鴨居 功樹, 高瀬 博, 杉田 直.
    • Journal Title

      臨床眼科

      Volume: 69 Pages: 1323-1327

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-surround division technique devised for posterior polar cataract surgery.2015

    • Author(s)
      Koju Kamoi.
    • Journal Title

      Ocular Surgery News APAO edition.

      Volume: 3 Pages: 40-45

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] New effective surgical technique for patients with posterior polar cataracts. Cataract News Today.2015

    • Author(s)
      Koju Kamoi.
    • Journal Title

      Cataract News Today.

      Volume: 3

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] Pre-surround division technique devised for posterior polar cataract surgery.2015

    • Author(s)
      Koju Kamoi.
    • Journal Title

      Ocular Surgery News U.S. Edition.

      Volume: 2

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus.2014

    • Author(s)
      Hiroshi Takase, Reo Kubono, Yukiko Terada, Ayano Imai, Shoko Fukuda, Makoto Tomita, Masaru Miyanaga, Koju Kamoi, Sunao Sugita, Kazunori Miyata, Manabu Mochizuki.
    • Journal Title

      Jpn. J. Ophthalmol.

      Volume: 58 Issue: 6 Pages: 473-482

    • DOI

      10.1007/s10384-014-0340-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pre-surround division technique: Precise cracks surrounding the posterior opacity prior to phacoemulsification in posterior polar cataract surgery.2014

    • Author(s)
      Koju Kamoi, Manabu Mochizuki.
    • Journal Title

      J Cataract Refract Surg.

      Volume: 40 Issue: 11 Pages: 1764-1767

    • DOI

      10.1016/j.jcrs.2014.09.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 白内障2014

    • Author(s)
      鴨居功樹
    • Journal Title

      けあふる

      Volume: 5 Pages: 6-7

    • Related Report
      2014 Research-status Report
  • [Journal Article] 白内障2014

    • Author(s)
      鴨居功樹
    • Journal Title

      眼科ケア

      Volume: 4 Pages: 329-331

    • Related Report
      2014 Research-status Report
  • [Journal Article] Behçet's disease ocular attack score 24: evaluation of ocular disease activity before and after initiation of infliximab.2014

    • Author(s)
      Kaburaki T, Namba K, Sonoda KH, Kezuka T, Keino H, Fukuhara T, Kamoi K, Nakai K, Mizuki N, Ohguro N; Ocular Behçet Disease Research Group of Japan
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58(2) Issue: 2 Pages: 120-130

    • DOI

      10.1007/s10384-013-0294-0

    • NAID

      40020019721

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ocular Behcet Disease Research Group of Japan. Behcet's disease ocular attack score 24: evaluation of ocular disease activity before and after initiation of infliximab.2014

    • Author(s)
      Kaburaki T, Namba K, Sonoda KH, Kezuka T, Keino H, Fukuhara T, Kamoi K, Nakai K, Mizuki N, Ohguro N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58 Issue: 1 Pages: 120-130

    • DOI

      10.1007/s10384-013-0283-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ぶどう膜炎2013

    • Author(s)
      鴨居功樹
    • Journal Title

      小児科

      Volume: 54 Pages: 863-869

    • Related Report
      2013 Research-status Report
  • [Presentation] HTLV-1感染と眼疾患.2015

    • Author(s)
      鴨居功樹.
    • Organizer
      東京眼科集談会
    • Place of Presentation
      千代田区放送会館(東京・千代田区)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 両眼性肉芽腫性汎ぶどう膜炎像を呈したEBウイルス陽性Tリンパ増殖症の2例.2015

    • Author(s)
      高橋洋如, 高瀬博, 新井文子, 寺田裕紀子, 鴨居功樹, 望月學, 大野京子.
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] HTLV-1ぶどう膜炎の診療に関する全国アンケート調査.2015

    • Author(s)
      鴨居功樹, 岡山昭彦, 大野京子.
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ATL関連眼疾患に関する診療の現状:全国アンケート調査結果.2015

    • Author(s)
      鴨居功樹, 岡山昭彦, 大野京子.
    • Organizer
      第2回日本HTLV-1学会
    • Place of Presentation
      東京大学医科学研究所(東京・港区)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] The role of HTLV-1 infected RPE cells in the pathogenesis of HTLV-1 uveitis.2015

    • Author(s)
      Koju Kamoi, Zhaorong Guo, Shintaro ,Horie, Kyoko Ohno-Matsui.
    • Organizer
      ARVO Annual Meeteing
    • Place of Presentation
      デンバー・アメリカ
    • Year and Date
      2015-05-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HTLV-1ぶどう膜炎の発症における網膜色素上皮細胞へのHTLV-1感染の関与.2015

    • Author(s)
      鴨居 功樹, 郭 曌蓉, 堀江 真太郎, 大野京子.
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 東京におけるHTLV-1ぶどう膜炎の臨床的特徴.2015

    • Author(s)
      井出 光広, 鴨居 功樹, 望月 學, 大野 京子.
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Targeted delivery of self-antigen to dendritic cells attenuates uveoretinitis in mice.2015

    • Author(s)
      Izabela P. Klaska, Lucia Kuffova, Koju Kamoi, Corina Bobu, Christina Martin-Granados, Ralph M. Steinman, John V. Forrester.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2015-03-08 – 2015-03-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Analysis of complications in patients with HTLV-1 uveitis.2015

    • Author(s)
      Koju Kamoi, Yukiko Terada, Kazunori Miyata, Manabu Mochizuki, Kyoko Ohno-Matsui.
    • Organizer
      Asia-ARVO
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-02-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 造血器悪性疾患に合併した眼底病変に対する前房水を用いた包括的感染症PCRの有用性2014

    • Author(s)
      川口龍史, 尾碕憲子, 村上喜三雄, 鴨居功樹 , 高瀬博 , 杉田直.
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 急性型ATLとHTLV-1ぶどう膜炎の同時発症の1例.2014

    • Author(s)
      平野 光人, 大野 伸広, 小林 誠一郎, 石垣 知寛, 田野崎 隆二, 鴨居 功樹, 望月 學, 内丸 薫, 東條 有伸.
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] HTLV-1キャリアに合併した関節リウマチにおける生物学的製剤の使用でHTLV―1ぶどう膜炎とHTLV-1関連脊髄症が悪化した1例.2014

    • Author(s)
      寺田 裕紀子, 鴨居 功樹, 山野 ちなみ, 山野 嘉久.
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] HTLV-1ぶどう膜炎の臨床像.2014

    • Author(s)
      鴨居 功樹, 寺田 裕紀子, 宮田 和典, 望月 學.
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] アダリムマブ導入でベーチェット病のぶどう膜炎を抑制できた一例.2014

    • Author(s)
      軽部央子, 鴨居功樹, 堀江真太郎, 高瀬博, 大野京子, 望月學.
    • Organizer
      第48回日本眼炎症学会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 東京医科歯科大学における眼トキソカラ症の検討.2014

    • Author(s)
      福地麗, 宮永将, 高瀬博, 鴨居功樹, 横田眞子, 赤尾信明, 望月學.
    • Organizer
      第25回日本臨床寄生虫学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Association of HTLV-1 uveitis with systemic inflammatory diseases and adult T cell leukemia.2014

    • Author(s)
      Koju Kamoi, Yukiko Terada, Kazunori Miyata, Manabu Mochizuki.
    • Organizer
      The Association for Research in Vision and Ophthalmology Annual Meeting
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2014-05-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Myeloid/NK cell precursor acute leukemiaの経過中に眼内浸潤がみられた1例.2014

    • Author(s)
      鈴木 さやか, 鴨居 功樹, 高瀬 博, 大野 京子, 富澤 大輔.
    • Organizer
      第118回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 東京医科歯科大学におけるぶどう膜炎臨床統計 1998年~2001年と2007年~2011年の比較.

    • Author(s)
      宮永将、高瀬博、鴨居功樹、川添裕子、窪野怜央、川口龍史、中島由季子、神田紗也香、高橋任美、石塚敦子、福地麗、杉田直、望月學
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] 東京医科歯科大学における眼トキソカラ症の検討.

    • Author(s)
      福地麗、宮永将、高瀬博、鴨居功樹、横田眞子、望月學、赤尾信明.
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] ヘルペス性前部ぶどう膜炎の臨床像の比較解析.

    • Author(s)
      窪野怜央、高瀬博、寺田裕紀子、宮永将、鴨居功樹、杉田直、富田誠、望月學.
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] HTLV-1ぶどう膜炎の臨床像の検討.

    • Author(s)
      寺田裕紀子、鴨居功樹、小溝崇史、子島良平、宮田和典、望月學.
    • Organizer
      第47回日本眼炎症学会.
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] ステロイド投与後に広汎な後極部壊死を生じた眼トキソプラズマ症の一例

    • Author(s)
      高橋洋如、高瀬博、岩崎優子、宮永将、今井彩乃、鴨居功樹、望月學.
    • Organizer
      第47回日本眼炎症学会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 新しいベーチェット病ぶどう膜炎の活動性スコアの評価の再現性の検討.

    • Author(s)
      蕪城俊克、南場研一、園田康平、毛塚剛司、慶野博、福原崇子、鴨居功樹、中井慶
    • Organizer
      第47回日本眼炎症学会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2013 Research-status Report
  • [Book] Intraocular Inflammation.2016

    • Author(s)
      Kamoi K, Mochizuki M.
    • Total Pages
      1530
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Intraocular Inflammation2015

    • Author(s)
      Koju Kamoi, Mochizuki Manabu
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report
  • [Book] 緑内障診療クローズアップ:ぶどう膜炎に続発する緑内障2014

    • Author(s)
      鴨居功樹
    • Total Pages
      276
    • Publisher
      メジカルビュー社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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