Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Outline of Final Research Achievements |
The subretinal injection of the lipid hydroperoxide 13(S)-Hydroperoxy-9Z,11E-octadecadienoic acid (HpODE) induced the choroidal neovascularization (CNV) in rat eyes. The incidence of HpODE-induced CNV was reduced in rats treated with thioredoxin (TRX) compared with the control. The concentration of vascular endothelial growth factor (VEGF) was lower in the tissue fluid of rat eyes treated with TRX compared with the control, so TRX may suppress the CNV by reducing the production of VEGF in the rat eyes.
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