The role of intraocular peroxisome proliferator-activated receptor gamma in patients with proliferative diabetic retinopathy

Research Project

Project/Area Number	25861634
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	The University of Tokushima
Principal Investigator	KATOME Takashi 徳島大学, 大学病院, 助教 (50464342)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	糖尿病網膜症 / VEGF / PPARγ / 増殖糖尿病網膜症 / 抗VEGF抗体 / 血管新生
Outline of Final Research Achievements	PPARγ concentrations in aqueous humor and vitreous fluid were significantly higher in PDR than in control (P<0.0005). In PDR, there were significant positive correlations between PPARγ and VEGF concentrations (P<0.0005). There was a tendency toward higher PPARγ concentrations in PDR patients with increasing severity of fibrous proliferation. PPARγ may be a promising candidate as a diagnostic marker and a therapeutic target for PDR.

Report

(3 results)