Identification of genes associated with the development of organ lesions in sarcoidosis

• Project/Area Number: 25861643
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Yokohama City University
• Principal Investigator: SHIBUYA Etsuko 横浜市立大学, 医学部, 助教 (70597228)
• Research Collaborator: MIZUKI Nobuhisa ; MEGURO Akira ; SATO Mayuki
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: サルコイドーシス / 遺伝子

Outline of Final Research Achievements

Sarcoidosis is a chronic systemic disease characterized by the accumulation of non-caseating granulomas in a wide range of organs such as lungs, lymph nodes, eye, skin and heart. The etiology of sarcoidosis is still uncertain, but the disease is currently thought to be triggered by various genetic as well as environmental factors.
In this study, we investigated genetic factors associated with each organ legion in sarcoidosis using a genome-wide association study data in a Japanese population and identified several genes that may contribute to the development of each organ legion.

Research Products

• [Journal Article] Development and validation of new diagnostic criteria for acute retinal necrosis. (2015)
  • Author(s): Takase H, Okada AA, Goto H, Mizuki N, Namba K, Ohguro N, Sonoda KH, Tomita M, Keino H, Kezuka T, Kubono R, Mizuuchi K, Shibuya E, Takahashi H, Yanai R, Mochizuki M
  • Journal Title: Jpn J Ophthalmol Volume: 59(1) Issue: 1 Pages: 14-20
  • DOI: 10.1007/s10384-014-0362-0
  • NAID: 210000165197
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the long-term efficacy and safety of infliximab treatment for uveitis in Behçet's disease: a multicenter study. (2014)
  • Author(s): Takeuchi M, Kezuka T, Sugita S, Keino H, Namba K, Kaburaki T, Maruyama K, Nakai K, Hijioka K, Shibuya E, Komae K, Hori J, Ohguro N, Sonoda KH, Mizuki N, Okada AA, Ishibashi T, Goto H, Mochizuki M
  • Journal Title: Ophthalmology Volume: 121(10) Issue: 10 Pages: 1877-1884
  • DOI: 10.1016/j.ophtha.2014.04.042
  • Peer Reviewed / Open Access
• [Journal Article] Postoperative refractive error following cataract surgery after the first attack of acute primary angle closure. (2014)
  • Author(s): Nishide T, Hayakawa N, Kimura I, Nakanishi M, Yagi Y, Shibuya E, Mizuki N
  • Journal Title: Int Ophthalmol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Reduction in choroidal thickness of macular area in polypoidal choroidal vasculopathy patients after intravitreal ranibizumab therapy. (2013)
  • Author(s): Nishide T, Hayakawa N, Nakanishi M, Ishii M, Okazaki S, Kimura I, Shibuya E, Mizuki N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 251(10) Issue: 10 Pages: 2415-2420
  • DOI: 10.1007/s00417-013-2419-z
  • Peer Reviewed
• [Journal Article] Preoperative factors associated with improvement in visual acuity after globe rupture treatment. (2013)
  • Author(s): Nishide T, Hayakawa N, Nakanishi M, Ishii M, Kimura I, Shibuya E, Nomura E, Mizuki N
  • Journal Title: Eur J Ophthalmol Volume: 23(5) Issue: 5 Pages: 718-722
  • DOI: 10.5301/ejo.5000252
  • Peer Reviewed
• [Journal Article] A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR (2013)
  • Author(s): Mizuki N
  • Journal Title: Ocul Immunol Inflamm. Volume: 21 Issue: 2 Pages: 150-2
  • DOI: 10.3109/09273948.2012.747619
  • Peer Reviewed