| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Age-related macular degeneration (AMD) is a major cause of severe vision loss. It is known that drusen, a hallmark of AMD, involves amyloid beta, which may play a role in the pathogenesis of AMD. Also age-related accumulation of lipid is supposed to be derived from lipoproteins secreted by retinal pigment epithelium (RPE). In the 3-D spheroid culture of RPE cells, inner cells lead to apoptosis, phagocytosed by an RPE monolayer formed at the surface and accompanied by outward secretion of lipoproteins. When spheroids are treated by secretase beta and gamma inhibitors, lipoproteins secretion and expression of elastin, a major component of Bruch’s membrane are reduced, suggesting that lipoprotein secretion should require remodeling of Bruch’s membrane.
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