| Project/Area Number |
25861645
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KOJIMA Kentaro 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40554762)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | サルコイドーシスぶどう膜炎 / プロテオミクス / 疾患特異的抗原 / 国際情報交換 |
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| Outline of Final Research Achievements |
In order to elucidate unknown disease specific antigen for ocular sarcoidosis, we have analyzed vitreous sample of sarcoidosis and non-sarcoidosis uveitis obtained at the time of vitrectomy surgery using proteomics. By comparing two groups, we were able to elucidate 15 differentially expressed annotated proteins spots, either unregulated or down regulated. These proteins are specific to sarcoidosis uveitis and by further analysis, there is a possibility to identify disease specific antigen for ocular sarcoidosis.
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