Melanocyte stem cells as a niche for corneal epithelial stem cells
| Project/Area Number |
25861650
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
SHIMMURA Shigeto 慶應義塾大学, 医学部(信濃町), 准教授 (00235780)
NIWANO Hiroko 慶應義塾大学, 医学部(信濃町), 研究員 (90748518)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 上皮幹細胞 / メラノサイト / 培養上皮シート / 角膜輪部上皮 / 幹細胞ニッチ / 角膜上皮幹細胞 |
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| Outline of Final Research Achievements |
Based on the localization of melanocytes in primary human limbal epithelial cell sheets, we hypothesized that melanocytes or melanocyte stem cells act as a limbal epithelial stem cell niche, even in vitro. However, our results suggested that although melanocytes in vitro supplied melanosome to the epithelial cells, melanocytes seemed to not have the additional effects on epithelial stem cells in vitro. Rather, limbal epithelial stem/progenitor cells seemed to maintain melanocytes in vitro. We intend to report our data including melanocyte localization in epithelial sheets by paper.
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Report
(3 results)
Research Products
(6 results)
