| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Our purpose was to develop and assess DMEK specific injector to reduce corneal endothelial damage with cultured corneal endothelial cell. DMEK injector, with which corneal endothelial cell was reduced 10% in vitro and 20% ex vivo, was used in corneal transplantation in bullous rabbit model. Protein expression of functional marker in cultured corneal cell was reinforce after transplantation. DMEK surgery was performed with injector, in result of non complication. Our results of using DMEK injector with cultured corneal endothelial sheet may help not only for donor graft, but for cultured corneal endothelial cell or iPS cell in clinical application.
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