Visual function and Pathogenesis of Experimental Optic Neuritis

Research Project

Project/Area Number	25861654
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Tokyo Medical University
Principal Investigator	Matsunaga Yoshimichi 東京医科大学, 医学部, 兼任助教 (20421050)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	神経眼科 / 視神経炎 / 視神経脊髄炎 / neurofascin / ago-glial junction / Neurofascin / 軸索障害 / 軸索変性 / 網膜 / 視力 / ミクログリア / 実験的自己免疫性視神経炎
Outline of Final Research Achievements	1.There is a possibility that functional axonal ｄｙsfunction precedes, pathological axonal damage in experimental optic neuritis. 2. Serum neurofascin may be a byproduct of axo-glial junction damage in patients with optic neuritis in neuromyelitis optica. 3. Anti-aquaporin-4 (AQP-4) antibody exists in the aqueous humor of AQP-4 positive optic neuritis patients. Therefore, there is a possibility that inner retinal layer thinning is a result of direct retinal damage.

Report

(4 results)