| Project/Area Number |
25861657
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Ueno Hiroki 聖マリアンナ医科大学, 医学部, 講師 (30529897)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 角膜stem/progenitor 細胞 / 角膜三叉神経 / 角膜Side population / 炎症細胞 / IL-1β / TNF-α / 角膜stem/progenitor細胞 / マクロファージ / IL-1beta / TNF-alpha / TGF-beta / ニューロトロフィン / 炎症反応 / 炎症性サイトカイン |
|---|
| Outline of Final Research Achievements |
Two corneal sutures were placed with 11-0 nylon between the mouse corneal center and the limbus to induce the inflammatory cell infiltration. As a result of determining the chronological change qualitatively and quantitatively, both corneal nerves and corneolimbal stem/progenitor cells are significantly reduced after infiltration of inflammatory cell. Therefore, the data suggest a critical role of inflammation in maintaining corneal stem/progenitor cells that formed the corneal stem cell niche and/or the corneal nerve.
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