| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The purpose of the study was to further investigate the cause and pathology of biliary atresia, and analyzed changes in gene expression in liver tissues of biliary atresia closely and comprehensively using gene microarray.
Liver tissue obtained by surgery from a patient with biliary atresia and other diseases as a control were used. RNA was extracted from liver tissue and microarray was performed. From the gene expression profile, 60 genes were up-regulated and 39 genes were down-regulated in biliary atresia. GO analysis suggested that several biological pathways related to immune and inflammatory responses may be involved in the development of biliary atresia.
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