Genetic research of pathogenesis and prognosis in biliary atresia with DNA microarray
Project/Area Number |
25861674
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatric surgery
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Research Institution | Nagoya University (2014-2016) Aichi Medical University (2013) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 胆道閉鎖症 / 遺伝子解析 / マイクロアレイ / DNA / DNAマイクロアレイ |
Outline of Final Research Achievements |
The purpose of the study was to further investigate the cause and pathology of biliary atresia, and analyzed changes in gene expression in liver tissues of biliary atresia closely and comprehensively using gene microarray. Liver tissue obtained by surgery from a patient with biliary atresia and other diseases as a control were used. RNA was extracted from liver tissue and microarray was performed. From the gene expression profile, 60 genes were up-regulated and 39 genes were down-regulated in biliary atresia. GO analysis suggested that several biological pathways related to immune and inflammatory responses may be involved in the development of biliary atresia.
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Report
(5 results)
Research Products
(9 results)
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[Presentation] Is laparoscopic Kasai portoenterostomy for biliary atresia minimally invasive? An evaluation of the associated perioperative alterations in inflammatory mediator, creatinine kinase, and liver enzyme levels.2016
Author(s)
Murase N, Uchida H, Tanano A, Shirota C, Hinoki A, Tainaka T, Yokota K, Oshima K, Shirotsuki R, Chiba K
Organizer
The 49th Annual Meeting of the Pacific Association of Pediatric Surgeons
Place of Presentation
Hawaii, USA
Year and Date
2016-04-24
Related Report
Int'l Joint Research
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