|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|Outline of Final Research Achievements
To clarify the possible application of near-infrared (NIR) irradiation to prevent skin flap necrosis, we evaluated the length of axial pattern flap survival in rats by NIR irradiation. A bilaterally symmetric island skin flap was elevated under the panniculus carnosus on the rat dorsum. Half of the flap was subjected to NIR irradiation just before flap elevation with a device that simulates solar radiation, which has a specialized contact cooling apparatus to avoid thermal effects. The length of flap survival of the NIR irradiated side was measured 7 days after flap elevation, and compared with the non-irradiated side. The irradiated side showed elongation of flap survival compared to the non-irradiated side. NIR irradiation increases the survival length of axial pattern flaps in rats. Our model is one the most practical models to evaluate flap survival in rats reflecting not only the effects of NIR irradiation but also drugs, cytokines, or cells.