Effect of Klotho gene on subcutaneous fat tissue and skin wound healing

Research Project

Project/Area Number	25861692
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Plastic surgery
Research Institution	Kindai University (2016) Sapporo Medical University (2013-2015)
Principal Investigator	YAMAUCHI Makoto 近畿大学, 医学部, 講師 (90438060)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	老化 / 病理学 / 免疫学
Outline of Final Research Achievements	Expression of Adiponectin mRNA was not significantly different between wild type and klotho deficient mice. LPS-induced TNF-α production was not suppressed in the presence of Secreted α-klotho protein but was significantly increased in the presence of FGF23. Thus, FGF23 may have a function to promote TNF-α production independently of α-klotho protein. In klotho deficientl mice, excess production of TNF-α in wounds might cause delay in wound healing.