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Analysis for the scar fomations assosiated MRTF-A

Research Project

Project/Area Number 25861696
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionIwate Medical University

Principal Investigator

NAGAO Munetomo  岩手医科大学, 医学部, 助教 (00364349)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords瘢痕 / ケロイド / MRTF-A / MRTF / 筋線維芽細胞
Outline of Final Research Achievements

Abnormal scar formations, for example, keloids and hypertrophic scars, are often caused by myofibroblasts. These cells contract the surrounding extracellular matrix resulting in the increased tissue density characteristic of scar tissue. However, its roles in abnormal scar formations are largely unknown. In this research, we showed that myocardin-related transcription factor-A (MRTF-A), a co-activator of serum response factor (SRF), mediates prohypertrophic signaling related between the scar formations and myofibroblasts. We used the methods by collagen gel contraction assay, stimulating MRTF inhibitor.
At the result, MRTF inhibitor suppressed the fibroblasts even if cell viability. However, our studies have expected the result to the potential therapeutic targets for the new treatment of abnormal scars.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (6 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] JSW scar scale 2011の改訂 -治療ガイドラインの作成に向けて-2015

    • Author(s)
      長尾宗朝 安岡智之 本多孝之 柏克彦 小林誠一郎
    • Journal Title

      瘢痕・ケロイド治療ジャーナル

      Volume: 9

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 有茎穿通枝皮弁による四肢の再建】 足・下肢 腓腹動脈穿通枝皮弁(SAP flap)2014

    • Author(s)
      柏克彦、小林誠一郎、長尾宗朝
    • Journal Title

      PEPARS

      Volume: 95 Pages: 71-82

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鼻唇溝皮弁による眼瞼周囲の再建2014

    • Author(s)
      柏克彦、小林誠一郎、柏谷元、長尾宗朝
    • Journal Title

      形成外科

      Volume: 57 Pages: 231-241

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血管可視化装置を用いた表在性静脈奇形の治療2013

    • Author(s)
      長尾宗朝、佐々木了、工藤信、柏克彦、小林誠一郎
    • Journal Title

      形成外科

      Volume: 56 Pages: 988-991

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 基礎疾患を有する患者の遊離皮弁移植術後合併症2013

    • Author(s)
      柏克彦、小林誠一郎、樋口浩文、長尾宗朝
    • Journal Title

      形成外科

      Volume: 56 Pages: 481-489

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 異常瘢痕におけるMRTFの局在の組織学的検討2015

    • Author(s)
      長尾宗朝、那須和佳子、真柳平、小林誠一郎、祖父江憲治
    • Organizer
      第24回日本形成外科学会基礎学術集会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2015-10-08 – 2015-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] パネルディスカッション JSW scar scale 2011の改訂 -治療ガイドラインの作成に向けて-2014

    • Author(s)
      長尾宗朝 安岡智之 本多孝之 柏克彦 小林誠一郎
    • Organizer
      第9回瘢痕・ケロイド治療研究会
    • Place of Presentation
      東京都
    • Year and Date
      2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ケロイド体質の予測は可能か-Fibrocyteとケロイド病態との関連性2013

    • Author(s)
      長尾宗朝
    • Organizer
      第56回日本形成外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 血管腫の診断と治療の実際2013

    • Author(s)
      長尾宗朝
    • Organizer
      第10回血管腫・血管奇形研究会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Maffucci症候群の治療経験2013

    • Author(s)
      長尾宗朝
    • Organizer
      第1回北海道・東北形成外科学会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 前額部腫瘤として認められた隆起性皮膚線維肉腫の1例2013

    • Author(s)
      長尾宗朝
    • Organizer
      第31回日本頭蓋顎顔面外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Book] 瘢痕・ケロイドはここまで治せる-ケロイド発症におけるfibrocyteの関与の可能性ー2015

    • Author(s)
      長尾宗朝 小林誠一郎
    • Total Pages
      234
    • Publisher
      克誠堂出版
    • Related Report
      2014 Annual Research Report
  • [Book] きずあと・ケロイドはここまで治せる2014

    • Author(s)
      小川令
    • Total Pages
      200
    • Publisher
      全日本病院出版社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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