Analysis of the tensile strength response in epidermal cell

• Project/Area Number: 25861704
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Keio University
• Principal Investigator: Tatsuya Kato 慶應義塾大学, 医学部(信濃町), 助教 (60641321)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 抗張力反応

Outline of Final Research Achievements

A decrease in Tissue inhibitor of metalloprotease-2 (TIMP2) was observed in keloid-like tissues in a mouse persistent tensile loading model. In epidermal cells, smooth muscle actin (SMA) was expressed by tensile strength. Administration of basic fibroblast growth factor suppressed expression of SMA, but decreased expression of TIMP2 was observed. In other words, epidermal cells subjected to tensile strength expressed SMA to antagonize the force. Furthermore, it was suggested that fibroblasts produced collagen to obtain further strengthen.