| Project/Area Number |
25861709
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Research Collaborator |
MATSUSHITA MASAYUKI 琉球大学, 医学部, 教授 (30273965)
LI XIAO-KONG(KO) 国立成育医療研究センター研究所, RI管理室, 室長 (60321890)
ARAKI JUN 東京大学, 医学部附属病院, 病院診療医 (00508088)
NAITO MUNEKAZU 愛知医科大学, 医学部, 教授 (10384984)
HIRAI SHUICHI 東京医科大学, 医学部, 准教授 (70516054)
ITOH MASAHIRO 東京医科大学, 医学部, 教授 (00232471)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再建外科学 / 臓器保存 / 高圧ガス / ラット / ブタ / 四肢 / 高圧ガス保存 / キセノン / 笑気ガス / ガス保存法 / 保存 / 高圧ガス保存法 / ラット切断肢 |
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| Outline of Final Research Achievements |
We demonstrated that exposure of rat amputated hind limbs into high-pressure medical gas without immersion in stock solution made it possible to long-term preservation. In addition, we revealed a part of mechanisms which carbon monoxide, xenon and dinitrous monoxide gas has cytoprotective effect for preservation. These results are important to show the scientific evidence and apply for clinical cases. Furthermore, we succeeded in pig amputated limb preservation by using high-pressure medical gases. This result indicates that high pressure gas preservation method can apply to organs of large animal and to have application potentiality in clinical scene.
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