| Project/Area Number |
25861739
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
OBA TOYOHARU 久留米大学, 医学部, 助教 (10389257)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | サイトカイン / 心筋保護 / プレコンディショニング / 臓器連関 / β2刺激 / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
Screened circulating cardioprotective JAK-STAT-activating cytokines in mice unexpectedly revealed increased serum erythropoietin (EPO) levels after formoteol injection. In mice, RIPC rapidly upregulated EPO mRNA and its main transcriptional factor, hypoxia-inducible factor-1α (HIF1α), in the kidney. Formoteol activated cardio-protective signaling pathways such as STAT3, AKT, ERK in mice heart, and reduced infarct size calculated by Evans-blue TTC staining. These results suggest that the activation of the HIF1α-EPO course in the kidney might bring reduction of the myocardial infarct size after the Formoteol dosage.
|
