Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning.

• Project/Area Number: 25861739
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kurume University
• Principal Investigator: OBA TOYOHARU 久留米大学, 医学部, 助教 (10389257)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: サイトカイン / 心筋保護 / プレコンディショニング / 臓器連関 / β2刺激 / シグナル伝達

Outline of Final Research Achievements

Screened circulating cardioprotective JAK-STAT-activating cytokines in mice unexpectedly revealed increased serum erythropoietin (EPO) levels after formoteol injection. In mice, RIPC rapidly upregulated EPO mRNA and its main transcriptional factor, hypoxia-inducible factor-1α (HIF1α), in the kidney. Formoteol activated cardio-protective signaling pathways such as STAT3, AKT, ERK in mice heart, and reduced infarct size calculated by Evans-blue TTC staining. These results suggest that the activation of the HIF1α-EPO course in the kidney might bring reduction of the myocardial infarct size after the Formoteol dosage.

Research Products

• [Journal Article] Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning. (2015)
  • Author(s): Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T.
  • Journal Title: Circulation journal Volume: ahead of print
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac-Specific SOCS3 Deletion Prevents in vivo myocardial ischemia reperfusion injury through sustained activation of cardioprotective signaling Molecules. (2015)
  • Author(s): Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, Minami T, Mawatari K, Sugi Y, Shimozono K, Pradervand S, Hoshijima M, Aoki H, Fukumoto Y, Imaizumi T.
  • Journal Title: PLOS ONE Volume: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms. (2014)
  • Author(s): Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N.
  • Journal Title: J Am Coll Cardiol Volume: 63 Issue: 24 Pages: 2722-2733
  • DOI: 10.1016/j.jacc.2014.03.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alterations in coxsackievirus and adenovirus receptor confer susceptibility to ventricular arrhythmia with an ischemic event (2014)
  • Author(s): Yasukawa H, Oba T, Fukumoto Y
  • Journal Title: J Am Coll Cardiol Volume: 63(6) Pages: 560-562
  • Peer Reviewed
• [Journal Article] Alterations in coxsackievirus and adenovirus receptor confer susceptibility to ventricular arrhythmia with an ischemic event. (2013)
  • Author(s): Yasukawa H, Oba T, Fukumoto Y.
  • Journal Title: J Am Coll Cardiol Volume: 63 Issue: 6 Pages: 560-562
  • DOI: 10.1016/j.jacc.2013.12.001
  • Peer Reviewed / Open Access
• [Journal Article] Respiratory variation of vertebral arterial flow in a patient scheduled for coronary artery bypass graft surgery: lesson from atypical subclavian steal phenomenon (2013)
  • Author(s): Anegawa T, Kai H, Fukuda K, Iwamoto Y, Tsuru T, Koiwaya H, Takeuchi T, Toyama Y, Oba T, Mawatari K, Takeuchi Y, Morioka M, Tanaka H, Ueno T, Imaizumi T
  • Journal Title: Circ J Volume: 77(9) Pages: 2412-2414
  • Peer Reviewed
• [Journal Article] Screening for Fabry disease in patients with left ventricular hypertrophy (2013)
  • Author(s): Mawatari K, Yasukawa H, Oba T, Nagata T, Togawa T, Tsukimura T, Kyogoku S, Ohshima H, Minami T, Sugi Y, Sakuraba H, Imaizumi T
  • Journal Title: Int J Cardiol Volume: 167(3) Pages: 1059-1061
  • Peer Reviewed
• [Presentation] Screening for Fabry disease in patients with left ventricular hypertrophy. (2014)
  • Author(s): Mawatari K, Yasukawa H, Oba T, Nagata T, Togawa T, Tsukimura T, Kyogoku S, Ohshima H, Minami T, Sugi Y, Imaizumi T.
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: さいたま
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Screening for fabry disease in patients with left ventricular hypertrophy (2013)
  • Author(s): Mawatari K, Yasukawa H, Oba T, Nagata T, Kyogoku S, Ohshima H, Minami T, Sugi Y, Imaizumi T
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: さいたま