Upregulation of cancer cell functions by apoptotic cell engulfment
Project/Area Number |
25861740
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphological basic dentistry
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 口腔癌 / 病理学 / アポトーシス / 貪食 / MFG-E8 |
Outline of Final Research Achievements |
Apoptotic oral squamous cell carcinoma (SCC) cells are engulfed by macrophages or even by neighboring SCC cells. We hypothesized that engulfment of apoptotic carcinoma cells by living carcinoma cells are promoted via MFG-E8, one of phagocytosis regulating molecules, and this phenomenon could contribute to tumor progression. Transient MFG-E8 overexpression in SCC cell lines increased migration, invasiveness, and engulfment of apoptotic cells. Thus we have demonstrated that MFG-E8 is involved in the clearance of apoptotic carcinoma cells by living carcinoma cells, and it might promote tumor progression in oral SCC.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.2013
Author(s)
Abe T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, Shingaki S, Kobayashi T, Hayashi T, Cheng J, Saku T.
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Journal Title
Human Pathology
Volume: 45(1)
Pages: 110-118
Related Report
Peer Reviewed
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[Journal Article] Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature.2013
Author(s)
Yamazaki M, Maruyama S, Abe T, Babkair H, Fujita H, Takagi R, Koyama J, Hayashi T, Cheng J, Saku T.
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Volume: -
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Peer Reviewed
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[Presentation] Osteolytic lesion of the maxilla2014
Author(s)
Yamazaki M,Maruyama S,Abe T, Nishikawa A, Takagi R, Nishiyama H, Hayashi T, Cheng J, Saku T.
Organizer
第25回日本臨床口腔病理学会総会・学術大会
Place of Presentation
新潟市 メディアシップ日報ホール
Year and Date
2014-08-27 – 2014-08-29
Related Report
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[Presentation] 口腔底腫瘍2013
Author(s)
山崎 学, 程 クン, 丸山 智, 阿部達也, 池田順行, 永田昌毅, 高木律男, 西山秀昌, 林 孝文, 朔 敬
Organizer
第24回 日本臨床口腔病理学会
Place of Presentation
東京都 日本大学
Related Report